Resveratrol-loaded nanocapsules inhibit murine melanoma tumor growth

被引：70
|
作者：
Carletto, Bruna [1 ]
Berton, Juliana [1 ]
Ferreira, Tamara Nascimento [1 ]
Dalmolin, Luciana Facco [1 ]
Paludo, Katia Sabrina [2 ]
Mainardes, Rubiana Mara [3 ]
Farago, Paulo Vitor [4 ]
Favero, Giovani Marino [5 ]
机构：
[1] Midwestern State Univ, Ponta Grossa State Univ, Postgrad Program Pharmaceut Sci, Brasilia, DF, Brazil
[2] Univ Estadual Ponta Grossa, Dept Struct Mol & Genet Biol, Ponta Grossa, PR, Brazil
[3] Midwestern State Univ, Dept Pharm, Brasilia, DF, Brazil
[4] Univ Estadual Ponta Grossa, Dept Pharmaceut Sci, Ponta Grossa, PR, Brazil
[5] Univ Estadual Ponta Grossa, Dept Gen Biol, BR-84030900 Ponta Grossa, Parana, Brazil
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2016年 / 144卷
关键词：
B16F10 Cell line; Nanoparticles; PCL; Phytoalexin; Polymeric drug carrier; DRUG-DELIVERY; IN-VIVO; NANOPARTICLES; PHARMACOKINETICS; ANTICANCER; CELLS; MECHANISMS; APOPTOSIS; THERAPY; BLEND;
D O I：
10.1016/j.colsurfb.2016.04.001
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
In this study, resveratrol-loaded nanocapsules were developed and its antitumor activity tested on a melanoma mice model. These nanocapsules were spherically-shaped and presented suitable size, negative charge and high encapsulation efficiency for their use as a modified-release system of resveratrol. Nanoencapsulation leads to the drug amorphization. Resveratrol-loaded nanoparticles reduced cell viability of murine melanoma cells. There was a decrease in tumor volume, an increase in the necrotic area and inflammatory infiltrate of melanoma when resveratrol-loaded nanocapsules were compared to free resveratrol in treated mice. Nanoencapsulation of resveratrol also prevented metastasis and pulmonary hemorrhage. This modified-release technology containing resveratrol can be used as a feasible approach in order to inhibit murine melanoma tumor growth. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：65 / 72
页数：8
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