Resveratrol-loaded nanocapsules inhibit murine melanoma tumor growth

被引：70
|
作者：
Carletto, Bruna [1 ]
Berton, Juliana [1 ]
Ferreira, Tamara Nascimento [1 ]
Dalmolin, Luciana Facco [1 ]
Paludo, Katia Sabrina [2 ]
Mainardes, Rubiana Mara [3 ]
Farago, Paulo Vitor [4 ]
Favero, Giovani Marino [5 ]
机构：
[1] Midwestern State Univ, Ponta Grossa State Univ, Postgrad Program Pharmaceut Sci, Brasilia, DF, Brazil
[2] Univ Estadual Ponta Grossa, Dept Struct Mol & Genet Biol, Ponta Grossa, PR, Brazil
[3] Midwestern State Univ, Dept Pharm, Brasilia, DF, Brazil
[4] Univ Estadual Ponta Grossa, Dept Pharmaceut Sci, Ponta Grossa, PR, Brazil
[5] Univ Estadual Ponta Grossa, Dept Gen Biol, BR-84030900 Ponta Grossa, Parana, Brazil
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2016年 / 144卷
关键词：
B16F10 Cell line; Nanoparticles; PCL; Phytoalexin; Polymeric drug carrier; DRUG-DELIVERY; IN-VIVO; NANOPARTICLES; PHARMACOKINETICS; ANTICANCER; CELLS; MECHANISMS; APOPTOSIS; THERAPY; BLEND;
D O I：
10.1016/j.colsurfb.2016.04.001
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
In this study, resveratrol-loaded nanocapsules were developed and its antitumor activity tested on a melanoma mice model. These nanocapsules were spherically-shaped and presented suitable size, negative charge and high encapsulation efficiency for their use as a modified-release system of resveratrol. Nanoencapsulation leads to the drug amorphization. Resveratrol-loaded nanoparticles reduced cell viability of murine melanoma cells. There was a decrease in tumor volume, an increase in the necrotic area and inflammatory infiltrate of melanoma when resveratrol-loaded nanocapsules were compared to free resveratrol in treated mice. Nanoencapsulation of resveratrol also prevented metastasis and pulmonary hemorrhage. This modified-release technology containing resveratrol can be used as a feasible approach in order to inhibit murine melanoma tumor growth. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：65 / 72
页数：8
相关论文
共 50 条
  • [1] Resveratrol-Loaded Lipid-Core Nanocapsules Treatment Reduces In Vitro and In Vivo Glioma Growth
    Figueiro, Fabricio
    Bernardi, Andressa
    Frozza, Rudimar L.
    Terroso, Thatiana
    Zanotto-Filho, Alfeu
    Jandrey, Elisa H. F.
    Moreira, Jose Claudio F.
    Salbego, Christianne G.
    Edelweiss, Maria I.
    Pohlmann, Adriana R.
    Guterres, Silvia S.
    Battastini, Ana Maria O.
    JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2013, 9 (03) : 516 - 526
  • [2] Resveratrol-loaded polymeric nanoparticles suppress glucose metabolism and tumor growth in vitro and in vivo
    Jung, Kyung-Ho
    Lee, Jin Hee
    Park, Jin Won
    Cung Hoa Thien Quach
    Moon, Seung-Hwan
    Cho, Young Seok
    Lee, Kyung-Han
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2015, 478 (01) : 251 - 257
  • [3] Resveratrol-loaded liposomes: Interaction of resveratrol with phospholipids
    Balanc, Bojana D.
    Ota, Ajda
    Djordjevic, Verica B.
    Sentjurc, Marjeta
    Nedovic, Viktor A.
    Bugarski, Branko M.
    Ulrih, Natasa Poklar
    EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 2015, 117 (10) : 1615 - 1626
  • [4] Resveratrol-loaded nanomedicines for cancer applications
    Annaji, Manjusha
    Poudel, Ishwor
    Boddu, Sai H. S.
    Arnold, Robert D.
    Tiwari, Amit K.
    Babu, R. Jayachandra
    CANCER REPORTS, 2021, 4 (03)
  • [5] Resveratrol-loaded proniosomes: Formulation, characterization and fortification
    Shruthi, P. A.
    Pushpadass, Heartwin A.
    Franklin, Magdaline Eljeeva Emerald
    Battula, Surendra Nath
    Naik, N. Laxmana
    LWT-FOOD SCIENCE AND TECHNOLOGY, 2020, 134
  • [6] ANTICONVULSANT ACTIVITY OF RESVERATROL-LOADED LIPOSOMES IN VIVO
    Ethemoglu, M. S.
    Seker, F. B.
    Akkaya, H.
    Kilic, E.
    Aslan, I.
    Erdogan, C. S.
    Yilmaz, B.
    NEUROSCIENCE, 2017, 357 : 12 - 19
  • [7] Apatinib-loaded nanoparticles inhibit tumor growth and angiogenesis in a model of melanoma
    Zhang, Ju
    Liu, Panpan
    Zhang, Zirui
    Han, Jing
    Yang, Xu
    Wang, Aimin
    Zhang, Xiaochun
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 521 (02) : 296 - 302
  • [8] Resveratrol-loaded peptide-hydrogels inhibit scar formation in wound healing through suppressing inflammation
    Zhao, Chen-Chen
    Zhu, Lian
    Wu, Zheng
    Yang, Rui
    Xu, Na
    Liang, Liang
    REGENERATIVE BIOMATERIALS, 2020, 7 (01) : 99 - 108
  • [9] Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice
    de Oliveira, Maria Talita Pacheco
    Coutinho, Diego de Sa
    Guterres, Silvia Staniscuaski
    Pohlmann, Adriana Raffin
    Rodrigues e Silva, Patricia Machado
    Martins, Marco Aurelio
    Bernardi, Andressa
    PHARMACEUTICS, 2021, 13 (05)
  • [10] Resveratrol-Loaded Lipid Nanocarriers Are Internalized By Endocytosis in Yeast
    Barbosa, Celia
    Santos-Pereira, Catia
    Soares, Ines
    Martins, Viviana
    Terra-Matos, Joana
    Corte-Real, Manuela
    Lucio, Marlene
    Real Oliveira, M. E. C. D.
    Geros, Hernani
    JOURNAL OF NATURAL PRODUCTS, 2019, 82 (05): : 1240 - 1249
12345