Resveratrol-loaded nanocapsules inhibit murine melanoma tumor growth

被引：72

作者：

Carletto, Bruna ^{[1
]}

Berton, Juliana ^{[1
]}

Ferreira, Tamara Nascimento ^{[1
]}

Dalmolin, Luciana Facco ^{[1
]}

Paludo, Katia Sabrina ^{[2
]}

Mainardes, Rubiana Mara ^{[3
]}

Farago, Paulo Vitor ^{[4
]}

Favero, Giovani Marino ^{[5
]}

机构：

[1] Midwestern State Univ, Ponta Grossa State Univ, Postgrad Program Pharmaceut Sci, Brasilia, DF, Brazil

[2] Univ Estadual Ponta Grossa, Dept Struct Mol & Genet Biol, Ponta Grossa, PR, Brazil

[3] Midwestern State Univ, Dept Pharm, Brasilia, DF, Brazil

[4] Univ Estadual Ponta Grossa, Dept Pharmaceut Sci, Ponta Grossa, PR, Brazil

[5] Univ Estadual Ponta Grossa, Dept Gen Biol, BR-84030900 Ponta Grossa, Parana, Brazil

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2016年 / 144卷

关键词：

B16F10 Cell line; Nanoparticles; PCL; Phytoalexin; Polymeric drug carrier; DRUG-DELIVERY; IN-VIVO; NANOPARTICLES; PHARMACOKINETICS; ANTICANCER; CELLS; MECHANISMS; APOPTOSIS; THERAPY; BLEND;

D O I：

10.1016/j.colsurfb.2016.04.001

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

In this study, resveratrol-loaded nanocapsules were developed and its antitumor activity tested on a melanoma mice model. These nanocapsules were spherically-shaped and presented suitable size, negative charge and high encapsulation efficiency for their use as a modified-release system of resveratrol. Nanoencapsulation leads to the drug amorphization. Resveratrol-loaded nanoparticles reduced cell viability of murine melanoma cells. There was a decrease in tumor volume, an increase in the necrotic area and inflammatory infiltrate of melanoma when resveratrol-loaded nanocapsules were compared to free resveratrol in treated mice. Nanoencapsulation of resveratrol also prevented metastasis and pulmonary hemorrhage. This modified-release technology containing resveratrol can be used as a feasible approach in order to inhibit murine melanoma tumor growth. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：65 / 72

页数：8

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