PKM2 promotes stemness of breast cancer cell by through Wnt/β-catenin pathway

被引：35
|
作者：
Zhao, Zheng [1 ,2 ]
Song, Zhangjun [3 ]
Liao, Zijun [2 ]
Liu, Zhigang [2 ]
Sun, Haifeng [2 ]
Lei, Baoxia [2 ]
Chen, Wenjuan [2 ]
Dang, Chengxue [1 ]
机构：
[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Coll Med, Dept Oncol, Xian 710061, Shaanxi, Peoples R China
[2] Shaanxi Prov Tumor Hosp, Dept Med Oncol 3, Xian 710061, Peoples R China
[3] Shaanxi Prov Tumor Hosp, Breast Canc Program, Xian 710061, Peoples R China
来源：
TUMOR BIOLOGY | 2016年 / 37卷 / 03期
关键词：
Pyruvate kinase isozymes M2; Cancer stem cell; beta-Catenin; Stemness; Holoclone; SELF-RENEWAL; PROGENITOR CELLS; IDENTIFICATION; PYRUVATE; DIFFERENTIATION; EXPRESSION; LEUKEMIA; TUMORS;
D O I：
10.1007/s13277-015-4121-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Metastasis is one of the main causes of breast cancer (BCa)-related deaths in female. It has been reported that cancer stem cell played an important role in metastasis. Here we first revealed a specific role of pyruvate kinase isozymes M2 (PKM2) in the stemness of breast cancer cells. Breast cancer tissue analysis confirmed the upregulation of PKM2 in breast cancer, and high PKM2 levels were associated with poor prognosis of breast cancer patients. Holoclone assay and colony formation assay significantly elucidated the role of PKM2 in the self-renewal of breast cancer cells. Moreover, PKM2 elevated the proportion of stem cell and the ability of sphere formation in breast cancer cells. PKM2 played its functional role in stemness by regulating beta-catenin. Collectively, we identified critical roles of PKM2 in the stemness of breast cancer cells which may elevate the therapeutic effect on breast cancer patients.
引用
收藏
页码：4223 / 4234
页数：12
相关论文
共 50 条
  • [41] PROX1 promotes breast cancer invasion and metastasis through WNT/β-catenin pathway via interacting with hnRNPK
    Zhu, Lizhe
    Tian, Qi
    Gao, Huan
    Wu, Kaijie
    Wang, Bo
    Ge, Guanqun
    Jiang, Siyuan
    Wang, Ke
    Zhou, Can
    He, Jianjun
    Liu, Peijun
    Ren, Yu
    Wang, Bin
    INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2022, 18 (05): : 2032 - 2046
  • [42] TRIP6 enhances stemness property of breast cancer cells through activation of Wnt/β-catenin
    Zhao, Xiaohui
    Jiang, Chao
    Xu, Rui
    Liu, Qingnan
    Liu, Guanglin
    Zhang, Yan
    CANCER CELL INTERNATIONAL, 2020, 20 (01)
  • [43] TRIP6 enhances stemness property of breast cancer cells through activation of Wnt/β-catenin
    Xiaohui Zhao
    Chao Jiang
    Rui Xu
    Qingnan Liu
    Guanglin Liu
    Yan Zhang
    Cancer Cell International, 20
  • [44] PKM2 promotes reductive glutamine metabolism
    Miao Liu
    Yuanyuan Wang
    Yuxia Ruan
    Changsen Bai
    Li Qiu
    Yanfen Cui
    Guoguang Ying
    Binghui Li
    Cancer Biology & Medicine, 2018, (04) : 389 - 399
  • [45] LncCCAT1 Promotes Breast Cancer Stem Cell Function through Activating WNT/β-catenin Signaling
    Tang, Tingting
    Guo, Changying
    Xia, Tiansong
    Zhang, Rui
    Zen, Ke
    Pan, Yi
    Jin, Liang
    THERANOSTICS, 2019, 9 (24): : 7384 - 7402
  • [46] Antitumor activity of galaxamide involved in cell apoptosis and stemness by inhibiting Wnt/β-catenin pathway in cervical cancer
    Yang, Guang
    He, Yunbiao
    Chen, Yingxing
    Huang, Zhihan
    Huang, Jieqiong
    Ren, Xinyi
    Xu, Shihai
    Li, Ping
    DRUG DEVELOPMENT RESEARCH, 2023, 84 (06) : 1114 - 1126
  • [47] Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration
    Magadum, Ajit
    Singh, Neha
    Kurian, Ann Anu
    Munir, Irsa
    Mehmood, Talha
    Brown, Kemar
    Sharkar, Mohammad Tofael Kabir
    Chepurko, Elena
    Sassi, Yassine
    Oh, Jae Gyun
    Lee, Philyoung
    Santos, Celio X. C.
    Gaziel-Sovran, Avital
    Zhang, Guoan
    Cai, Chen-Leng
    Kho, Changwon
    Mayr, Manuel
    Shah, Ajay M.
    Hajjar, Roger J.
    Zangi, Lior
    CIRCULATION, 2020, 141 (15) : 1249 - 1265
  • [48] PKM2 promotes reductive glutamine metabolism
    Liu, Miao
    Wang, Yuanyuan
    Ruan, Yuxia
    Bai, Changsen
    Qiu, Li
    Cui, Yanfen
    Ying, Guoguang
    Li, Binghui
    CANCER BIOLOGY & MEDICINE, 2018, 15 (04) : 389 - +
  • [49] Transmembrane protein TMEM119 facilitates the stemness of breast cancer cells by activating Wnt/β-catenin pathway
    Yang, Ben
    Wang, Fengling
    Zheng, Gang
    BIOENGINEERED, 2021, 12 (01) : 4856 - 4867
  • [50] IGF-1-mediated PKM2/β-catenin/miR-152 regulatory circuit in breast cancer
    Yi-Yang Wen
    Wei-Tao Liu
    Hao-Ran Sun
    Xin Ge
    Zhu-Mei Shi
    Min Wang
    Wei Li
    Jian-Ying Zhang
    Ling-Zhi Liu
    Bing-Hua Jiang
    Scientific Reports, 7
12345