PKM2 promotes stemness of breast cancer cell by through Wnt/β-catenin pathway

被引：36
作者：
Zhao, Zheng [1 ,2 ]
Song, Zhangjun [3 ]
Liao, Zijun [2 ]
Liu, Zhigang [2 ]
Sun, Haifeng [2 ]
Lei, Baoxia [2 ]
Chen, Wenjuan [2 ]
Dang, Chengxue [1 ]
机构：
[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Coll Med, Dept Oncol, Xian 710061, Shaanxi, Peoples R China
[2] Shaanxi Prov Tumor Hosp, Dept Med Oncol 3, Xian 710061, Peoples R China
[3] Shaanxi Prov Tumor Hosp, Breast Canc Program, Xian 710061, Peoples R China
来源：
TUMOR BIOLOGY | 2016年 / 37卷 / 03期
关键词：
Pyruvate kinase isozymes M2; Cancer stem cell; beta-Catenin; Stemness; Holoclone; SELF-RENEWAL; PROGENITOR CELLS; IDENTIFICATION; PYRUVATE; DIFFERENTIATION; EXPRESSION; LEUKEMIA; TUMORS;
D O I：
10.1007/s13277-015-4121-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Metastasis is one of the main causes of breast cancer (BCa)-related deaths in female. It has been reported that cancer stem cell played an important role in metastasis. Here we first revealed a specific role of pyruvate kinase isozymes M2 (PKM2) in the stemness of breast cancer cells. Breast cancer tissue analysis confirmed the upregulation of PKM2 in breast cancer, and high PKM2 levels were associated with poor prognosis of breast cancer patients. Holoclone assay and colony formation assay significantly elucidated the role of PKM2 in the self-renewal of breast cancer cells. Moreover, PKM2 elevated the proportion of stem cell and the ability of sphere formation in breast cancer cells. PKM2 played its functional role in stemness by regulating beta-catenin. Collectively, we identified critical roles of PKM2 in the stemness of breast cancer cells which may elevate the therapeutic effect on breast cancer patients.
引用
收藏
页码：4223 / 4234
页数：12
相关论文
共 50 条
  • [31] CAV1 Promotes HCC Cell Progression and Metastasis through Wnt/β-Catenin Pathway
    Yu, Hongxiu
    Shen, Huali
    Zhang, Yang
    Zhong, Fan
    Liu, Yinkun
    Qin, Lunxiu
    Yang, Pengyuan
    PLOS ONE, 2014, 9 (09):
  • [32] Sohlh2 inhibits breast cancer cell proliferation by suppressing Wnt/-catenin signaling pathway
    Zhang, Xiaoli
    Liu, Ruihua
    Zhao, Na
    Ji, Shufang
    Hao, Chunyan
    Cui, Weiwei
    Zhang, Ruihong
    Hao, Jing
    MOLECULAR CARCINOGENESIS, 2019, 58 (06) : 1008 - 1018
  • [33] Activation of the Wnt pathway through Wnt2 promotes metastasis in pancreatic cancer
    Jiang, Hua
    Li, Qingqing
    He, Chengzhi
    Li, Fengru
    Sheng, Haihui
    Shen, Xiaoying
    Zhang, Xiaoyan
    Zhu, Shizhang
    Chen, Hui
    Chen, Ximei
    Yang, Changqing
    Gao, Hengjun
    AMERICAN JOURNAL OF CANCER RESEARCH, 2014, 4 (05): : 537 - 544
  • [34] PKM2: a new player in the β-catenin game
    Canal, Frederic
    Perret, Christine
    FUTURE ONCOLOGY, 2012, 8 (04) : 395 - 398
  • [35] LGR5 Promotes Breast Cancer Progression and Maintains Stem-Like Cells Through Activation of Wnt/β-Catenin Signaling
    Yang, Lu
    Tang, Hailin
    Kong, Yanan
    Xie, Xinhua
    Chen, Jianping
    Song, Cailu
    Liu, Xiaoping
    Ye, Feng
    Li, Ning
    Wang, Neng
    Xie, Xiaoming
    STEM CELLS, 2015, 33 (10) : 2913 - 2924
  • [36] miR-942 promotes cancer stem cell-like traits in esophageal squamous cell carcinoma through activation of Wnt/β-catenin signalling pathway
    Ge, Chunlei
    Wu, Shikai
    Wang, Weiwei
    Liu, Zhimin
    Zhang, Jianhua
    Wang, Zhenyu
    Li, Ruilei
    Zhang, Zhiwei
    Li, Zhen
    Dong, Suwei
    Wang, Ying
    Xue, Yuanbo
    Yang, Jinyan
    Tan, Qinghua
    Wang, Ziping
    Song, Xin
    ONCOTARGET, 2015, 6 (13) : 10964 - 10977
  • [37] Tissue transglutaminase-1 promotes stemness and chemoresistance in gastric cancer cells by regulating Wnt/β-catenin signaling
    Huang, Haitao
    Chen, Zhiqi
    Ni, Xiuqin
    EXPERIMENTAL BIOLOGY AND MEDICINE, 2017, 242 (02) : 194 - 202
  • [38] MiR-182 promotes prostate cancer progression through activating Wnt/β-catenin signal pathway
    Wang, Dawei
    Lu, Guoliang
    Shao, Yuan
    Xu, Da
    BIOMEDICINE & PHARMACOTHERAPY, 2018, 99 : 334 - 339
  • [39] Targeting the Wnt/β-catenin signaling pathway in cancer
    Zhang, Ya
    Wang, Xin
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2020, 13 (01)
  • [40] PKM2 depletion induces the compensation of glutaminolysis through β-catenin/c-Myc pathway in tumor cells
    Wu, Haili
    Li, Zongwei
    Yang, Peng
    Zhang, Lichao
    Fan, Yongsheng
    Li, Zhuoyu
    CELLULAR SIGNALLING, 2014, 26 (11) : 2397 - 2405
12345