The stomach cancer pooling (StoP) project: study design and presentation

被引：64

作者：

Pelucchi, Claudio ^{[1
]}

Lunet, Nuno ^{[5
,6
]}

Boccia, Stefania ^{[3
,4
]}

Zhang, Zuo-Feng ^{[7
,8
]}

Praud, Delphine ^{[1
,2
]}

Boffetta, Paolo ^{[9
,10
]}

Levi, Fabio ^{[15
]}

Matsuo, Keitaro ^{[16
]}

Ito, Hidemi ^{[17
]}

Hu, Jinfu ^{[18
]}

Johnson, Kenneth C. ^{[19
]}

Ferraroni, Monica ^{[2
]}

Yu, Guo-Pei ^{[33
]}

Peleteiro, Barbara ^{[5
,6
]}

Malekzadeh, Reza ^{[21
]}

Derakhshan, Mohammad H. ^{[21
,23
]}

Ye, Weimin ^{[24
]}

Zaridze, David ^{[26
]}

Maximovitch, Dmitry ^{[26
]}

Aragones, Nuria ^{[27
,28
,29
]}

Martin, Vicente ^{[28
,30
]}

Pakseresht, Mohammadreza ^{[20
,21
]}

Pourfarzi, Farhad ^{[21
,22
]}

Bellavia, Andrea ^{[25
]}

Orsini, Nicola ^{[25
]}

Wolk, Alicja ^{[25
]}

Mu, Lina ^{[12
]}

Arzani, Dario ^{[3
]}

Kurtz, Robert C. ^{[11
]}

Lagiou, Pagona ^{[31
,32
]}

Trichopoulos, Dimitrios ^{[13
,32
]}

Muscat, Joshua ^{[14
]}

La Vecchia, Carlo ^{[1
,2
]}

Negri, Eva ^{[1
]}

机构：

[1] IRCCS Ist Ric Farmacol Mario Negri, Dept Epidemiol, I-20156 Milan, Italy

[2] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy

[3] Univ Cattolica Sacro Cuore, Inst Publ Hlth, Sect Hyg, Rome, Italy

[4] IRCCS San Raffaele Pisana, Rome, Italy

[5] Univ Porto ISPUP, Inst Publ Hlth, Oporto, Portugal

[6] Univ Porto, Sch Med, Dept Clin Epidemiol Predict Med & Publ Hlth, P-4100 Oporto, Portugal

[7] Univ Calif Los Angeles, Dept Epidemiol, Fielding Sch Publ Hlth, Los Angeles, CA USA

[8] Jonsson Comprehens Canc Ctr, Los Angeles, CA 90034 USA

[9] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY USA

[10] Mt Sinai Sch Med, Inst Translat Epidemiol, New York, NY USA

[11] Mem Sloan Kettering Canc Ctr, Rockville Ctr, New York, NY 10065 USA

[12] SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Social & Prevent Med, Buffalo, NY 14260 USA

[13] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[14] Penn State Coll Med, Hershey, PA USA

[15] Univ Lausanne Hosp, Inst Social & Prevent Med IUMSP, Canc Epidemiol Unit, Lausanne, Switzerland

[16] Kyushu Univ, Fac Med Sci, Dept Prevent Med, Fukuoka 812, Japan

[17] Aichi Canc Ctr Res Inst, Div Epidemiol & Prevent, Nagoya, Aichi, Japan

[18] Publ Hlth Agcy Canada, Social Determinants & Sci Integrat Directorate, Sci Integrat Div, Calgary, AB, Canada

[19] Univ Ottawa, Dept Epidemiol & Community Hlth, Ottawa, ON, Canada

[20] Univ Alberta, Dept Med, Aboriginal & Global Hlth Res Grp, Edmonton, AB, Canada

[21] Univ Tehran Med Sci, Digest Dis Res Inst, Digest Oncol Res Ctr, Tehran, Iran

[22] Ardabil Univ Med Sci, Dept Community Med, Ardebil, Iran

[23] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland

[24] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[25] Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-10401 Stockholm, Sweden

[26] Russian NN Blokhin Canc Res Ctr, Dept Epidemiol & Prevent, Moscow, Russia

[27] Inst Salud Carlos III, Natl Ctr Epidemiol, Environm & Canc Epidemiol Unit, Madrid, Spain

[28] CIBERESP, Madrid, Spain

[29] IIS Puerta Hierro, Majadahonda, Spain

[30] Univ Leon, E-24071 Leon, Spain

[31] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[32] Acad Athens, Bur Epidemiol Res, Athens, Greece

[33] Peking Univ, Med Informat Ctr, Beijing, Peoples R China

来源：

EUROPEAN JOURNAL OF CANCER PREVENTION | 2015年 / 24卷 / 01期

关键词：

consortia; epidemiology; pooled analysis; risk factors; stomach neoplasms; HELICOBACTER-PYLORI INFECTION; CONTROL CONSORTIUM PANC4; GASTRIC-CANCER; POOLED ANALYSIS; EPIDEMIOLOGY CONSORTIUM; ALCOHOL-DRINKING; REPLACEMENT THERAPY; INTERNATIONAL HEAD; CHINESE POPULATION; PANCREATIC-CANCER;

D O I：

10.1097/CEJ.0000000000000017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastric cancer affects about one million people per year worldwide, being the second leading cause of cancer mortality. The study of its etiology remains therefore a global issue as it may allow the identification of major targets, besides eradication of Helicobacter pylori infection, for primary prevention. It has however received little attention, given its comparatively low incidence in most high-income countries. We introduce a consortium of epidemiological investigations named the Stomach cancer Pooling (StoP) Project'. Twenty-two studies agreed to participate, for a total of over 9000 cases and 23 000 controls. Twenty studies have already shared the original data set. Of the patients, 40% are from Asia, 43% from Europe, and 17% from North America; 34% are women and 66% men; the median age is 61 years; 56% are from population-based case-control studies, 41% from hospital-based ones, and 3% from nested case-control studies derived from cohort investigations. Biological samples are available from 12 studies. The aim of the StoP Project is to analyze the role of lifestyle and genetic determinants in the etiology of gastric cancer through pooled analyses of individual-level data. The uniquely large data set will allow us to define and quantify the main effects of each risk factor of interest, including a number of infrequent habits, and to adequately address associations in subgroups of the population, as well as interaction within and between environmental and genetic factors. Further, we will carry out separate analyses according to different histotypes and subsites of gastric cancer, to identify potential different risk patterns and etiological characteristics. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：16 / 23

页数：8