CRISPR Cas9 in Pancreatic Cancer Research

被引：13

作者：

Yang, Hai ^{[1
]}

Bailey, Peter ^{[1
]}

Pilarsky, Christian ^{[1
]}

机构：

[1] Univ Klinikum Erlangen, Dept Surg Res, Erlangen, Germany

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2019年 / 7卷

关键词：

pancreatic cancer; CRISPR; Cas9; gene editing; knock out and knock in; library screening; ONE-STEP GENERATION; POOR-PROGNOSIS; IN-VIVO; GENE; RNA; IDENTIFICATION; RESISTANCE; DELIVERY; MICE;

D O I：

10.3389/fcell.2019.00239

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pancreatic cancer is now becoming a common cause of cancer death with no significant change in patient survival over the last 10 years. The main treatment options for pancreatic cancer patients are surgery, radiation therapy and chemotherapy, but there is now considerable effort to develop new and effective treatments. In recent years, CRISPR/Cas9 technology has emerged as a powerful gene editing tool with promise, not only as an important research methodology, but also as a new and effective method for targeted therapy. In this review, we summarize current advances in CRISPR/Cas9 technology and its application to pancreatic cancer research, and importantly as a means of selectively targeting key drivers of pancreatic cancer.

引用

页数：6

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