Cell type-specific neuronal loss in the putamen of patients with multiple system atrophy

被引：10

作者：

Sato, Kenta

Kaji, Ryuji

Matsumoto, Sadayuki

Goto, Satoshi ^{[1
]}

机构：

[1] Univ Tokushima, Grad Sch Med, Inst Hlth Biosci, Dept Clin Neurosci, Tokushima 7708503, Japan

[2] Kitano Hosp, Dept Neurol, Osaka, Japan

[3] Neurol Ctr, Osaka, Japan

来源：

MOVEMENT DISORDERS | 2007年 / 22卷 / 05期

关键词：

multiple system atrophy; striatum; neurodegeneration; choline acetyltransferase; medium spiny neurons;

D O I：

10.1002/mds.21385

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Using antibodies to calcineurin (CaN) and choline acetyltransferase (ChAT), we performed topographical and cellular immunohistochemical analysis on the posterior putamen of autopsied patients with multiple system atrophy with predominant parkinsonism (MSA-P). We document that in these patients, medium spiny neurons positive for CaN were severely depleted in the dorsolateral portion of the posterior putamen where ChAT-positive neurons are normally distributed. Our findings indicate that in patients with MSA-P, striatal neurons manifest a cell type-specific vulnerability to neurodegeneration. (c) 2007 Movement Disorder Society.

引用

页码：738 / 742

页数：5

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