Association of IL-12A and IL-12B polymorphisms with Alzheimer's disease susceptibility in a Han Chinese population

被引：30

作者：

Zhu, Xi-Chen ^{[1
]}

Tan, Lan ^{[1
,2
,3
]}

Jiang, Teng ^{[1
]}

Tan, Meng-Shan ^{[3
]}

Zhang, Wei ^{[2
]}

Yu, Jin-Tai ^{[1
,2
,3
]}

机构：

[1] Nanjing Med Univ, Qingdao Municipal Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China

[2] Qingdao Univ, Sch Med, Dept Neurol, Qingdao Municipal Hosp, Qingdao, Peoples R China

[3] Ocean Univ China, Coll Med & Pharmaceut, Qingdao Municipal Hosp, Dept Neurol, Qingdao, Peoples R China

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2014年 / 274卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

Alzheimer's disease; IL-12; Polymorphism; Pro-inflammatory cytokine; Gene; Association; GENETIC ASSOCIATION; INTERLEUKIN-12; RISK; INHIBITION;

D O I：

10.1016/j.jneuroim.2014.06.026

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

As a pro-inflammatory cytokine belonging to the interleukin (IL)-1 family, IL-12 is recently found to be involved in the pathogenesis of Alzheimer's disease (AD). Here, we investigated the relations of three potentially functional single nucleotide polymorphisms (SNPs) in IL-12A (rs2243115 and rs568408) and IL-12B (rs3212227) with late-onset AD (LOAD) risk in a Northern Han Chinese cohort containing 1133 patients and 1158 healthy controls. Our findings indicated that these SNPs in IL-12A and IL-12B can individually and jointly contribute to LOAD risk in Han Chinese, implying that the genes encoding IL-12 subunits represent novel genetic risk factors for LOAD susceptibility. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：180 / 184

页数：5

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