Gold- and Platinum-Catalyzed Formal Markownikoff's Double Hydroamination of Alkynes: A Rapid Access to Tetrahydroquinazolinones and Angularly-Fused Analogues Thereof

被引：63

作者：

Patil, Nitin T. ^{[1
]}

Kavthe, Rahul D. ^{[1
]}

Raut, Vivek S. ^{[1
]}

Shinde, Valmik S. ^{[1
]}

Sridhar, Balasubramanian ^{[2
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 2, Hyderabad 500607, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Lab Xray Crystallog, Hyderabad 500607, Andhra Pradesh, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 04期

关键词：

INTRAMOLECULAR HYDROAMINATION; INTERMOLECULAR HYDROAMINATION; ORGANIC-SYNTHESIS; ATOM ECONOMY; CASCADE; CYCLIZATION; HYDROALKOXYLATION; HYDROARYLATION; QUINAZOLINE; ACTIVATION;

D O I：

10.1021/jo902293f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient gold(I)- and platinum(II)-catalyzed process for formal Markownikoffs double hydroamination of alkynes tethered with hydroxyl group has been developed. The method was shown to be applicable to a broad range of 2-aminobenzamides and alkynols leading to the formation of multiply substituted tetrahydro-quinazolinones. Interestingly, when Pt(IV)Cl-4 catalyst was employed, cyclic angularly fused compound was obtained.

引用

页码：1277 / 1280

页数：4

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