Altered motor performance in Alzheimer's disease: a dynamic analysis using EEG
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作者:
Allouch, Sahar
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机构:
Lebanese Univ, EDST, Azm Ctr Res Biotechnol & Its Applicat, Tripoli, LebanonLebanese Univ, EDST, Azm Ctr Res Biotechnol & Its Applicat, Tripoli, Lebanon
Allouch, Sahar
[1
]
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机构:
Tabbal, Judie
[1
,2
]
Nasser, Assef
论文数: 0引用数: 0
h-index: 0
机构:
Vita Nova Polyclin, Tripoli, LebanonLebanese Univ, EDST, Azm Ctr Res Biotechnol & Its Applicat, Tripoli, Lebanon
Nasser, Assef
[3
]
Hassan, Mahmoud
论文数: 0引用数: 0
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机构:
INSERM, U1099, LTSI, F-35000 Rennes, FranceLebanese Univ, EDST, Azm Ctr Res Biotechnol & Its Applicat, Tripoli, Lebanon
Hassan, Mahmoud
[2
]
Khalil, Mohamad
论文数: 0引用数: 0
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机构:
Lebanese Univ, EDST, Azm Ctr Res Biotechnol & Its Applicat, Tripoli, Lebanon
Lebanese Univ, Fac Engn, CRSI Res Ctr, Tripoli, LebanonLebanese Univ, EDST, Azm Ctr Res Biotechnol & Its Applicat, Tripoli, Lebanon
Khalil, Mohamad
[1
,4
]
Kabbara, Aya
论文数: 0引用数: 0
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机构:
INSERM, U1099, LTSI, F-35000 Rennes, FranceLebanese Univ, EDST, Azm Ctr Res Biotechnol & Its Applicat, Tripoli, Lebanon
Kabbara, Aya
[2
]
机构:
[1] Lebanese Univ, EDST, Azm Ctr Res Biotechnol & Its Applicat, Tripoli, Lebanon
[2] INSERM, U1099, LTSI, F-35000 Rennes, France
[3] Vita Nova Polyclin, Tripoli, Lebanon
[4] Lebanese Univ, Fac Engn, CRSI Res Ctr, Tripoli, Lebanon
来源:
2019 FIFTH INTERNATIONAL CONFERENCE ON ADVANCES IN BIOMEDICAL ENGINEERING (ICABME)
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2019年
关键词:
Alzheimer' s disease;
Electroencephalography;
motor task;
static analysis;
dynamic analysis;
BRAIN NETWORKS;
MEG;
SYNCHRONIZATION;
CONNECTIVITY;
ATROPHY;
D O I:
暂无
中图分类号:
R318 [生物医学工程];
学科分类号:
0831 ;
摘要:
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive memory impairment and cognitive deficits. Many previous studies assumed stationarity of the brain activity while quantifying differences between AD patients and controls. However, the human brain is a dynamic system, and cognitive processes may change at sub-second timescale. The main objective of this study is to investigate the advantage of dynamic analysis over static analysis in detecting the brain alterations occurred in AD. Therefore, using electroencephalography data recorded from 10 AD patients and 12 healthy elderly controls while performing a motor task, we investigated the channel-level differences in voltage distribution between AD and controls with both, static and dynamic approaches. While static analysis showed similar response for both groups, dynamic analysis revealed significant differences in different brain regions during the first 200 ms following stimulus onset. These findings highlight the necessity of adopting a dynamic analysis when exploring brain activity differences between AD and controls.