RETRACTED: In Silico Identification of Hub Genes as Observing Biomarkers for Gastric Cancer Metastasis (Retracted Article)

被引：8

作者：

Ajucarmelprecilla, Arulprakasam ^{[1
]}

Pandi, Jhansi ^{[1
,2
]}

Dhandapani, Ranjithkumar ^{[3
]}

Ramanathan, Saikishore ^{[1
]}

Chinnappan, Jayaprakash ^{[3
]}

Paramasivam, Ragul ^{[2
]}

Thangavelu, Sathiamoorthi ^{[1
]}

Ghilan, Abdul-Kareem Mohammed ^{[4
]}

Aljohani, Saad Ali S. ^{[5
]}

Oyouni, Atif Abdulwahab A. ^{[6
,7
]}

Farasani, Abdullah ^{[8
,9
]}

Altayar, Malik A. ^{[10
]}

Althagafi, Hussam Awwadh E. ^{[11
]}

Alzahrani, Othman R. ^{[6
,7
]}

Durairaj, Kaliannan ^{[12
]}

Shrestha, Anupama ^{[13
,14
]}

机构：

[1] Alagappa Univ, Dept Microbiol, Med Microbiol Unit, Karaikkudi, Tamil Nadu, India

[2] Chimertech Private Ltd, Chennai, Tamil Nadu, India

[3] Bharathiar Univ, Dept Bioinformat, Coimbatore, Tamil Nadu, India

[4] King Saud Univ, Coll Sci, Dept Bot & Microbiol, POB 2455, Riyadh 11451, Saudi Arabia

[5] Alrayan Coll, Fac Med, Dept Basic Med Sci, Al Munawarrah, Saudi Arabia

[6] Univ Tabuk, Fac Sci, Dept Biol, Tabuk, Saudi Arabia

[7] Univ Tabuk, Fac Sci, Genome & Biotechnol Unit, Tabuk, Saudi Arabia

[8] Jazan Univ, Med Res Ctr, Biomed Res Unit, Jazan 45142, Saudi Arabia

[9] Jazan Univ, Coll Appl Med Sci, Dept Med Lab Technol, Jazan 45142, Saudi Arabia

[10] Univ Tabuk, Fac Appl Med Sci, Dept Med Lab Technol, Tabuk, Saudi Arabia

[11] Al Baha Univ, Fac Sci & Arts, Biol Dept, Al Mikhwah, Saudi Arabia

[12] Wonkwang Univ, Zoonosis Res Ctr, Sch Med, Iksan, South Korea

[13] Res Inst Agr & Appl Sci, Tokha Kathmandu 2356, Nepal

[14] Himalayan Coll Agr Sci & Technol, Dept Plant Protect, Kathmandu 44600, Nepal

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2022年 / 2022卷

关键词：

HUMAN CDC45; EXPRESSION; MUTATIONS; SURVIVAL; PSMA7; BUBR1;

D O I：

10.1155/2022/6316158

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Perception of hub genes engaged in metastatic gastric cancer (mGC) promotes novel ways to diagnose and treat the illness. The goal of this investigation is to recognize the hub genes and reveal its molecular mechanism. In order to explore the potential facts for gastric cancer, the expression profiles of two different datasets were used (GSE161533 and GSE54129). The genes were confirmed to be part of the PPI network for gastric cancer pathogenesis and prognosis. In Cytoscape, the CytoHubba module was used to discover the hub genes. Responsible hub genes were identified. Data from Kaplan-Meier plotter confirmed the predictive value of these distinct genes in various stages of gastric malignancy. Upregulated and downregulated genes were identified to utilize for further analysis. Positive regulation by a host of viral process, positive regulation of granulocyte differentiation, negative regulation of histone H-3-K-9 methylation were found in DEGs analysis. In addition, five KEGG pathways were identified as an essential enhancer that include nucleotide excision repair; base excision repair; DNA replication; homologous recombination; and complement and coagulation cascades. POLE, BUB1B, POLD4, C3, BLM, CCT7, PRPF31, APEX1, PSMA7, and CDC45 were chosen as hub genes after combining the PPI results. Our study recommends that BUB1B, CCT7, APEX1, PSMA7, and CDC45 might be potential biomarkers for gastric cancer. These biomarkers are upregulated genes. Therefore, suppression of these genes will increase the survival rate in gastric cancer patients.

引用

页数：12

共 34 条

[1] Investigating the pathogenic SNPs in BLM helicase and their biological consequences by computational approach [J].

Alzahrani, Faisal A. ;

Ahmed, Firoz ;

Sharma, Monika ;

Rehan, Mohd ;

Mahfuz, Maryam ;

Baeshen, Mohammed N. ;

Hawsawi, Yousef ;

Almatrafi, Ahmed ;

Alsagaby, Suliman Abdallah ;

Kamal, Mohammad Azhar ;

Warsi, Mohiuddin Khan ;

Choudhry, Hani ;

Jamal, Mohammad Sarwar .

SCIENTIFIC REPORTS, 2020, 10 (01)

[2] The functions of animal microRNAs [J].

Ambros, V .

NATURE, 2004, 431 (7006) :350-355

[3] High expression of BUBR1 is one of the factors for inducing DNA aneuploidy and progression in gastric cancer [J].

Ando, Koji ;

Kakeji, Yosihiro ;

Kitao, Hiroyuki ;

Iimori, Makoto ;

Zhao, Yan ;

Yoshida, Rintaro ;

Oki, Eiji ;

Yoshinaga, Keiji ;

Matumoto, Takuya ;

Morita, Masaru ;

Sakaguchi, Yoshihisa ;

Maehara, Yoshihiko .

CANCER SCIENCE, 2010, 101 (03) :639-645

[4] An automated method for finding molecular complexes in large protein interaction networks [J].

Bader, GD ;

Hogue, CW .

BMC BIOINFORMATICS, 2003, 4 (1)

[5] Polymerase ε (POLE) Mutations in Endometrial Cancer: Clinical Outcomes and Implications for Lynch Syndrome Testing [J].

Billingsley, Caroline C. ;

Cohn, David E. ;

Mutch, David G. ;

Stephens, Julie A. ;

Suarez, Adrian A. ;

Goodfellow, Paul J. .

CANCER, 2015, 121 (03) :386-394

[6]

Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21492, 10.3322/caac.21609]

[7] cytoHubba: identifying hub objects and sub-networks from complex interactome [J].

Chin, Chia-Hao ;

Chen, Shu-Hwa ;

Wu, Hsin-Hung ;

Ho, Chin-Wen ;

Ko, Ming-Tat ;

Lin, Chung-Yen .

BMC SYSTEMS BIOLOGY, 2014, 8

[8] CDH1 germline mutations and hereditary lobular breast cancer [J].

Corso, Giovanni ;

Intra, Mattia ;

Trentin, Chiara ;

Veronesi, Paolo ;

Galimberti, Viviana .

FAMILIAL CANCER, 2016, 15 (02) :215-219

[9] PSMA7, A Potential Biomarker of Diseases [J].

Du, Hongyan ;

Huang, Xiang ;

Wang, Suihai ;

Wu, Yingsong ;

Xu, Weiwen ;

Li, Ming .

PROTEIN AND PEPTIDE LETTERS, 2009, 16 (05) :486-489

[10] Genome-wide survey of tissue-specific microRNA and transcription factor regulatory networks in 12 tissues [J].

Guo, Zhiyun ;

Maki, Miranda ;

Ding, Ruofan ;

Yang, Yalan ;

Zhang, Bao ;

Xiong, Lili .

SCIENTIFIC REPORTS, 2014, 4

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