Synthesis and antibacterial activity of novel lincomycin derivatives. I. Enhancement of antibacterial activities by introduction of substituted azetidines

被引：12

作者：

Kumura, Ko ^{[1
]}

Wakiyama, Yoshinari ^{[1
]}

Ueda, Kazutaka ^{[1
]}

Umemura, Eijiro ^{[1
]}

Watanabe, Takashi ^{[1
]}

Shitara, Eiki ^{[1
]}

Fushimi, Hideki ^{[1
]}

Yoshida, Takuji ^{[1
]}

Ajito, Keiichi ^{[1
]}

机构：

[1] Meiji Seika Pharma Co Ltd, Pharmaceut Res Ctr, Yokohama, Kanagawa, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2016年 / 69卷 / 06期

关键词：

D O I：

10.1038/ja.2015.134

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The synthesis and antibacterial activity of (7S)-7-sulfur-azetidin-3-yl lincomycin derivatives are described. Modification was achieved by a simple reaction of (7R)-7-O-methanesulfonyllincomycin and the corresponding substituted azetidine-2-thiol. Several compounds first showed moderate antibacterial activity against Streptococcus pneumoniae and Streptococcus pyogenes with erm gene as lincomycin derivatives.

引用

页码：440 / 445

页数：6

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[1] Synthesis and antibacterial activity of novel lincomycin derivatives. I. Enhancement of antibacterial activities by introduction of substituted azetidines
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[2] Synthesis of novel lincomycin derivatives and their in vitro antibacterial activities
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