Use of Antibacterial Agents in Renal Failure

被引：19

作者：

Gilbert, Brett ^{[1
]}

Robbins, Paul ^{[2
]}

Livornese, Lawrence L., Jr. ^{[3
]}

机构：

[1] Lankenau Hosp, Thomas Jefferson Univ Hosp, Dept Med, Div Infect Dis, Wynnewood, PA 19096 USA

[2] Lankenau Hosp, Dept Med, Div Nephrol, Wynnewood, PA 19096 USA

[3] Drexel Univ, Lankenau Hosp, Coll Med, Div Infect Dis,Dept Med, Wynnewood, PA 19096 USA

来源：

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 2009年 / 23卷 / 04期

关键词：

Antibiotics; Renal failure; Volume of distribution; MDRD; Dosing antibiotics with dialysis; Pharmacokinetics; Dosing antibiotics with continuous renal replacement therapy; Serum levels; GLOMERULAR-FILTRATION-RATE; STAPHYLOCOCCUS-AUREUS; SIEVING COEFFICIENTS; CREATININE CLEARANCE; SERUM CREATININE; VANCOMYCIN; HEMODIALYSIS; PHARMACOKINETICS; CEFAZOLIN; TRIMETHOPRIM;

D O I：

10.1016/j.idc.2009.06.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This article provides background information on the pharmacokinetics of antibacterial agents in patients who have normal and impaired renal function. Tables are provided to allow quick determination of appropriate dosages for varying degrees of renal failure. The use of serum levels; newer strategies for cefazolin, vancomycin and aminoglycoside dosing; methods of dialysis and associated antibiotics dosage adjustments, and antibiotic toxicity in renal failure are reviewed.

引用

页码：899 / +

页数：27

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