A retrospective case notes review of the effectiveness and tolerability of metoclopramide in the treatment of clozapine-induced hypersalivation (CIH)

被引：3

作者：

Livermore, Cecilia ^{[1
]}

White, Hannah ^{[1
]}

Bailey, Loren ^{[1
]}

Osborne, Ian ^{[1
,2
]}

Oloyede, Ebenezer ^{[1
,2
,3
]}

Dzahini, Olubanke ^{[1
,2
]}

Whiskey, Eromona ^{[1
,2
]}

机构：

[1] South London & Maudsley NHS Fdn Trust, Pharm Dept, Denmark Hill, London SE5 8AZ, England

[2] Kings Coll London, Inst Pharmaceut Sci, London, England

[3] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England

来源：

BMC PSYCHIATRY | 2022年 / 22卷 / 01期

关键词：

Clozapine; Metoclopramide; Hypersalivation; Adverse effect; DOUBLE-BLIND;

D O I：

10.1186/s12888-022-03940-0

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective The objective of the study is to explore the long-term effectiveness and tolerability of metoclopramide in the treatment of CIH. Method This study is a retrospective, observational cohort study of patients prescribed metoclopramide for CIH at the South London & Maudsley (SLaM) NHS Foundation Trust. Results Of the 96 patients identified, 14 patients were eligible for inclusion in our study. Five patients continued treatment with a mean duration of 27 months (SD = 17.8), and one patient continued until transfer with a duration of 3 months. Eight patients discontinued treatment after a mean duration of 8 months. Conclusion Metoclopramide may be an effective and tolerated drug in CIH, but more data is required to establish its place in the pharmacotherapy of this condition.

引用

页数：6

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