Rab GEFs and GAPs

被引：331

作者：

Barr, Francis ^{[1
]}

Lambright, David G. ^{[2
,3
]}

机构：

[1] Univ Liverpool, Canc Res Ctr, Liverpool L3 9TA, Merseyside, England

[2] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA

[3] Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, Worcester, MA 01605 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2010年 / 22卷 / 04期

基金：

英国惠康基金;

关键词：

GUANINE-NUCLEOTIDE-EXCHANGE; GTPASE-ACTIVATING PROTEIN; CANINE KIDNEY-CELLS; STRUCTURAL BASIS; CRYSTAL-STRUCTURE; LEGIONELLA-PNEUMOPHILA; EARLY ENDOSOMES; COILED-COIL; C-ELEGANS; BIOCHEMICAL-CHARACTERIZATION;

D O I：

10.1016/j.ceb.2010.04.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rabs are GTP-binding proteins with conserved functions in membrane trafficking. They are regulated by a diverse group of structurally unrelated GDP-GTP exchange factors (GEFs), and a family of GTP-hydrolysis activating proteins (GAPs) containing the conserved TBC domain. Recent structural and cell biological studies shed new light on the mechanisms of Rab GEF and GAP action, and the cellular trafficking pathways they act in.

引用

页码：461 / 470

页数：10

共 107 条

[1] Identification of the catalytic domains and their functionally critical arginine residues of two yeast GTPase-activating proteins specific for Ypt/Rab transport GTPases [J].

Albert, S ;

Will, E ;

Gallwitz, D .

EMBO JOURNAL, 1999, 18 (19) :5216-5225

[2] Two new members of a family of Ypt/Rab GTPase activating proteins - Promiscuity of substrate recognition [J].

Albert, S ;

Gallwitz, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (47) :33186-33189

[3] Msb4p, a protein involved in Cdc42p-dependent organization of the actin cytoskeleton, is a Ypt/Rab-specific GAP [J].

Albert, S ;

Gallwitz, D .

BIOLOGICAL CHEMISTRY, 2000, 381 (5-6) :453-456

[4] Mutation in rab3 GTPase-activating protein (RAB3GAP) noncatalytic subunit in a kindred with Martsolf syndrome [J].

Aligianis, IA ;

Morgan, NV ;

Mione, M ;

Johnson, CA ;

Rosser, E ;

Hennekam, RC ;

Adams, G ;

Trembath, RC ;

Pilz, DT ;

Stoodley, N ;

Moore, AT ;

Wilson, S ;

Maher, ER .

AMERICAN JOURNAL OF HUMAN GENETICS, 2006, 78 (04) :702-707

[5] Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro syndrome [J].

Aligianis, IA ;

Johnson, CA ;

Gissen, P ;

Chen, DR ;

Hampshire, D ;

Hoffmann, K ;

Maina, EN ;

Morgan, NV ;

Tee, L ;

Morton, J ;

Ainsworth, JR ;

Horn, D ;

Rosser, E ;

Cole, TRP ;

Stolte-Dijkstra, I ;

Fieggen, K ;

Clayton-Smith, J ;

Mégarbané, A ;

Shield, JP ;

Newbury-Ecob, R ;

Dobyns, WB ;

Graham, JM ;

Kjaer, KW ;

Warburg, M ;

Bond, J ;

Trembath, RC ;

Harris, LW ;

Takai, Y ;

Mundlos, S ;

Tannahill, D ;

Woods, CG ;

Maher, ER .

NATURE GENETICS, 2005, 37 (03) :221-223

[6] The Connecdenn DENN Domain: A GEF for Rab35 Mediating Cargo-Specific Exit from Early Endosomes [J].

Allaire, Patrick D. ;

Marat, Andrea L. ;

Dall'Armi, Claudia ;

Di Paolo, Gilbert ;

McPherson, Peter S. ;

Ritter, Brigitte .

MOLECULAR CELL, 2010, 37 (03) :370-382

[7] Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby Canine Kidney cells [J].

Babbey, Clifford M. ;

Ahktar, Nahid ;

Wang, Exing ;

Chen, Carlos Chih-Hsiung ;

Grant, Barth D. ;

Dunn, Kenneth W. .

MOLECULAR BIOLOGY OF THE CELL, 2006, 17 (07) :3156-3175

[8] Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase [J].

Brett, Christopher L. ;

Plemel, Rachael L. ;

Lobinger, Braden T. ;

Vignali, Marissa ;

Fields, Stanley ;

Merz, Alexey J. .

JOURNAL OF CELL BIOLOGY, 2008, 182 (06) :1141-1151

[9]

Brown TL, 1998, CURR BIOL, V8, pR191

[10] A MAMMALIAN GUANINE-NUCLEOTIDE-RELEASING PROTEIN ENHANCES FUNCTION OF YEAST SECRETORY PROTEIN SEC4 [J].

BURTON, J ;

ROBERTS, D ;

MONTALDI, M ;

NOVICK, P ;

DECAMILLI, P .

NATURE, 1993, 361 (6411) :464-467

← 1 2 3 4 5 6 7 8 9 10 →