Rab GEFs and GAPs

被引：327
作者：
Barr, Francis [1 ]
Lambright, David G. [2 ,3 ]
机构：
[1] Univ Liverpool, Canc Res Ctr, Liverpool L3 9TA, Merseyside, England
[2] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA
[3] Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, Worcester, MA 01605 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 2010年 / 22卷 / 04期
基金：
英国惠康基金;
关键词：
GUANINE-NUCLEOTIDE-EXCHANGE; GTPASE-ACTIVATING PROTEIN; CANINE KIDNEY-CELLS; STRUCTURAL BASIS; CRYSTAL-STRUCTURE; LEGIONELLA-PNEUMOPHILA; EARLY ENDOSOMES; COILED-COIL; C-ELEGANS; BIOCHEMICAL-CHARACTERIZATION;
D O I：
10.1016/j.ceb.2010.04.007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Rabs are GTP-binding proteins with conserved functions in membrane trafficking. They are regulated by a diverse group of structurally unrelated GDP-GTP exchange factors (GEFs), and a family of GTP-hydrolysis activating proteins (GAPs) containing the conserved TBC domain. Recent structural and cell biological studies shed new light on the mechanisms of Rab GEF and GAP action, and the cellular trafficking pathways they act in.
引用
收藏
页码：461 / 470
页数：10
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