A primer in cytokines

被引：36
作者：
Gosain, A [1 ]
Gamelli, RL [1 ]
机构：
[1] Loyola Univ, Med Ctr, Dept Surg, Burn & Shock Trauma Inst, Maywood, IL 60153 USA
来源：
JOURNAL OF BURN CARE & REHABILITATION | 2005年 / 26卷 / 01期
关键词：
D O I：
10.1097/01.BCR.0000150214.72984.44
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
The host response to injury or infection is a complex interplay of endocrine, metabolic, and immunological alterations designed to promote wound healing and restore the system to a state of homeostasis. Cytokines are the primary mediators of the inflammatory response to injury. This article serves as an introduction to this important class of inflammatory mediators. The major pro- and anti- inflammatory cytokines as well as the chemokines are discussed. Results from laboratory and clinical attempts at manipulation of these mediators are discussed and recommendations for future research in anticytokine therapy are made.
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页码：7 / 12
页数：6
相关论文
共 66 条
[1]   EFFICACY AND SAFETY OF MONOCLONAL-ANTIBODY TO HUMAN TUMOR-NECROSIS-FACTOR-ALPHA IN PATIENTS WITH SEPSIS SYNDROME - A RANDOMIZED, CONTROLLED, DOUBLE-BLIND, MULTICENTER CLINICAL-TRIAL [J].
ABRAHAM, E ;
WUNDERINK, R ;
SILVERMAN, H ;
PERL, TM ;
NASRAWAY, S ;
LEVY, H ;
BONE, R ;
WENZEL, RP ;
BALK, R ;
ALLRED, R ;
PENNINGTON, JE ;
WHERRY, JC .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 273 (12) :934-941
[2]  
Aggarwal Kunal, 2003, Briefings in Functional Genomics & Proteomics, V2, P175, DOI 10.1093/bfgp/2.3.175
[3]   Inflammatory bowel disease: the role of inflammatory cytokine gene polymorphisms [J].
Balding, J ;
Livingstone, WJ ;
Conroy, J ;
Mynett-Johnson, L ;
Weir, DG ;
Mahmud, N ;
Smith, OP .
MEDIATORS OF INFLAMMATION, 2004, 13 (03) :181-187
[4]   The tumor necrosis factor ligand and receptor families [J].
Bazzoni, F ;
Beutler, B .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (26) :1717-1725
[5]   GROWTH-FACTORS AND WOUND-HEALING - BIOCHEMICAL-PROPERTIES OF GROWTH-FACTORS AND THEIR RECEPTORS [J].
BENNETT, NT ;
SCHULTZ, GS .
AMERICAN JOURNAL OF SURGERY, 1993, 165 (06) :728-737
[6]   GROWTH-FACTORS AND WOUND-HEALING .2. ROLE IN NORMAL AND CHRONIC WOUND-HEALING [J].
BENNETT, NT ;
SCHULTZ, GS .
AMERICAN JOURNAL OF SURGERY, 1993, 166 (01) :74-81
[7]   PURIFICATION OF CACHECTIN, A LIPOPROTEIN-LIPASE SUPPRESSING HORMONE SECRETED BY ENDOTOXIN-INDUCED RAW 264.7 CELLS [J].
BEUTLER, B ;
MAHONEY, J ;
LETRANG, N ;
PEKALA, P ;
CERAMI, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1985, 161 (05) :984-995
[8]   IDENTITY OF TUMOR NECROSIS FACTOR AND THE MACROPHAGE-SECRETED FACTOR CACHECTIN [J].
BEUTLER, B ;
GREENWALD, D ;
HULMES, JD ;
CHANG, M ;
PAN, YCE ;
MATHISON, J ;
ULEVITCH, R ;
CERAMI, A .
NATURE, 1985, 316 (6028) :552-554
[9]   Role of early cytokines, including alpha and beta interferons (IFN-α/β), in innate and adaptive immune responses to viral infections [J].
Biron, CA .
SEMINARS IN IMMUNOLOGY, 1998, 10 (05) :383-390
[10]   HIGH CIRCULATING LEVELS OF INTERLEUKIN-6 IN PATIENTS WITH SEPTIC SHOCK - EVOLUTION DURING SEPSIS, PROGNOSTIC VALUE, AND INTERPLAY WITH OTHER CYTOKINES [J].
CALANDRA, T ;
GERAIN, J ;
HEUMANN, D ;
BAUMGARTNER, JD ;
GLAUSER, MP .
AMERICAN JOURNAL OF MEDICINE, 1991, 91 (01) :23-29
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