Recent insight into the biological activities of synthetic xanthone derivatives

被引：128
作者：
Shagufta [1 ]
Ahmad, Irshad [1 ]
机构：
[1] Amer Univ Ras Al Khaimah, Sch Arts & Sci, Dept Math & Nat Sci, Ras Al Khaymah, U Arab Emirates
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2016年 / 116卷
关键词：
Xanthones; Therapeutic agents; Biological activities; Anticancer; PROTEIN-KINASE-C; ALPHA-GLUCOSIDASE INHIBITORS; NONSTEROIDAL AROMATASE INHIBITORS; STRUCTURE-BASED DESIGN; ANTI-AIDS AGENTS; PHARMACOLOGICAL-PROPERTIES; ANTIPROLIFERATIVE ACTIVITY; CHOLINESTERASE-INHIBITORS; DRUG-RESISTANCE; DCX DERIVATIVES;
D O I：
10.1016/j.ejmech.2016.03.058
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Xanthones are a class of oxygen containing heterocyclic compounds with a broad range of biological activities, and they have prominent significance in the field of medicinal chemistry. Xanthone is an attractive scaffold for the design and development of new drugs due to its promising biological activities, primarily as anticancer, antimalarial, antimicrobial, anti-HIV, anticonvulsant, anticholinesterase, antioxidant, anti-inflammatory, and as inhibitors of several enzymes like a-glycosidase, topoisomerase, protein kinase, aromatase, etc. In this review, we have compiled and discussed recent developments on the pharmacological profile of synthetic xanthone derivatives for different therapeutic targets. The review highlights the therapeutic significance of xanthones and offers support in the development of new xanthone derivatives as therapeutic agents. (C) 2016 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：267 / 280
页数：14
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