SPECTRAL CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SOME TRANSITION METAL COMPLEXES OF 2-(5-NITRO-1H-BENZIMIDAZOL-2-YL)-4-BROMOPHENOL

被引：8
作者：
Tavman, Aydin [1 ]
Hacioglu, Mayram [2 ]
Gurbuz, Demet [1 ]
Cinarli, Adem [1 ]
Oksuzomer, M. A. Faruk [3 ]
Tan, A. Seher Birteksoz [2 ]
机构：
[1] Istanbul Univ Cerrahpasa, Fac Engn, Dept Chem, TR-34320 Istanbul, Turkey
[2] Istanbul Univ, Fac Pharm, Dept Pharmaceut Microbiol, TR-34452 Istanbul, Turkey
[3] Istanbul Univ Cerrahpasa, Fac Engn, Dept Chem Engn, TR-34320 Istanbul, Turkey
来源：
BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA | 2019年 / 33卷 / 03期
关键词：
Benzimidazole; Bromophenol; Transition metal complexes; Antibacterial; Antifungal; IRON(III) COMPLEXES; FT-IR; ANTIBACTERIAL; NICKEL(II); LIGANDS; BENZIMIDAZOLE; COPPER(II); COBALT(II); ZN(II); NI(II);
D O I：
10.4314/bcse.v33i3.6
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
MnCl2, FeCl3, Ru(DMSO)(4)Cl-2, CoCl2, NiCl2, PdCl2, CuCl2, AgNO3, CdCl2 and HgCl2 complexes of 2-(5-nitro-1H-benzimidazol-2-yl)-4-bromophenol (HL) were synthesized and characterized. The structures of the complexes were confirmed on the basis of elemental analysis, TGA, molar conductivity and magnetic moment measurements, FT-IR, far-IR, FT-Raman, UV-Visible, NMR and fluorescence spectroscopy. According to the analytical and spectral data, the ligand acted as bidentate, via the imine nitrogen and the phenolate oxygen atoms towards to the metal ions except the Ag(I). The complexes were screened for in vitro antibacterial activities against S. aureus, S. epidermidis, E. coli, K. pneumoniae, P. aeruginosa, P. mirabilis and for antifungal activity against C. albicans. Ciprofloxacin and fluconazole were used as reference for antibacterial and antifungal activities of the complexes, respectively. In most cases, the complexes tested showed considerable activity on S. aureus especially, which is a Gram positive bacterium. In addition, the Hg(II) and Ag(I) complexes were found to have superior activity toward all of the microorganisms whereas the Pd(II) and Cd(II) complexes showed considerably antimicrobial effect on S. aureus and C. albicans selectively.
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页码：451 / 466
页数：16
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