Serum HO-1 is useful to make differential diagnosis of secondary hemophagocytic syndrome from other similar hematological conditions

被引：18

作者：

Miyazaki, Takuya ^{[1
]}

Kirino, Yohei ^{[1
]}

Takeno, Mitsuhiro ^{[1
]}

Hama, Maasa ^{[1
]}

Ushihama, Ayumi ^{[1
]}

Watanabe, Reina ^{[1
]}

Takase, Kaoru ^{[2
]}

Tachibana, Takayoshi ^{[1
]}

Matsumoto, Kenji ^{[1
]}

Tanaka, Masatsugu ^{[1
]}

Yamaji, Satoshi ^{[1
]}

Ideguchi, Haruko ^{[2
]}

Tomita, Naoto ^{[1
]}

Fujita, Hiroyuki ^{[1
]}

Ohno, Shigeru ^{[2
]}

Ueda, Atsuhisa ^{[1
]}

Ishigatsubo, Yoshiaki ^{[1
]}

机构：

[1] Yokohama City Univ, Grad Sch Med, Dept Internal Med & Clin Immunol, Kanazawa Ku, Kanagawa 2360004, Japan

[2] Yokohama City Univ, Med Ctr, Ctr Rheumat Dis, Kanagawa 2360004, Japan

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2010年 / 91卷 / 02期

关键词：

Heme oxygenase; Hemophagocytic syndrome; Ferritin; Macrophage; ONSET STILLS-DISEASE; HEME OXYGENASE-1; IRON OVERLOAD; GUIDELINES; LYMPHOHISTIOCYTOSIS; HEME-OXYGENASE-1; MACROPHAGES; DEFICIENCY; MONOCYTES; LIVER;

D O I：

10.1007/s12185-010-0495-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heme oxygenase (HO)-1, a heme-degrading enzyme inducible by various stimuli, plays a key role in the regulation of inflammatory response in monocytes/macrophages. The serum HO-1 level is remarkably increased in patients with secondary hemophagocytic syndrome (HPS) or adult-onset Still's disease. We measured serum HO-1 levels in patients with a variety of hematological diseases, including secondary HPS, by means of ELISA. Serum HO-1 levels were significantly higher in 22 patients with HPS (134.7 +/- 116.2 ng/mL, P < 0.0001) at diagnosis than in 80 patients with other hematological diseases. The most effective cutoff point between HPS and other conditions was 14.5 ng/mL, with 100.0% sensitivity and 96.3% specificity. In HPS patients, the serum HO-1 levels showed the highest correlation with serum ferritin (r = 0.682, P = 0.0005), which reflects the disease activity of HPS. Moreover, both HO-1 and ferritin levels were reduced in parallel after successful treatment in patients with HPS, irrespective of underlying diseases. However, HO-1 levels were not elevated in patients with other causes of hyperferritinemia. These data demonstrate that serum HO-1 can distinguish secondary HPS from other hematological diseases, including those associated with hyperferritinemia.

引用

页码：229 / 237

页数：9