Inhibition of tumor necrosis factor-α-induced apoptosis by Asparagus cochinchinensis in Hep G2 cells

被引：34

作者：

Koo, HN

Jeong, HJ

Choi, JY

Choi, SD

Choi, TJ

Cheon, YS

Kim, KS

Kang, BK

Park, ST

Chang, CH

Kim, CH

Lee, YM

Kim, HM

An, NH

Kim, JJ

机构：

[1] Wonkwang Univ, Ctr Oriental Med Sci, Sch Med, Dept Anat, Chonbuk 570749, South Korea

[2] Wonkwang Univ, Ctr Oriental Med Sci, Sch Med, Coll Pharm, Chonbuk 570749, South Korea

[3] Wonkwang Univ, Ctr Oriental Med Sci, Sch Med, Dept Internal Med, Chonbuk 570749, South Korea

[4] Wonkwang Univ, Ctr Oriental Med Sci, Sch Med, Dept Otolaryngol Head & Neck Surg, Chonbuk 570749, South Korea

[5] DongGuk Univ, Coll Oriental Med, Dept Biochem & Mol Biol, Kyungju City 780714, Kyungpook, South Korea

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2000年 / 73卷 / 1-2期

关键词：

Asparagus cochinchinensis(MERRIL) (Liliaceae) roots; Hep G2 cells; ethanol; tumor necrosis factor-alpha; cytotoxicity; apoptosis;

D O I：

10.1016/S0378-8741(00)00287-7

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A human hepatoma cell line, Hep G2 cells, is a reliable system for the study of alcohol-induced hepatotoxicity. In this study, we investigated the effect of an aqueous extract of Asparagus cochinchinensis(MERRIL) (Liliaceae) roots (ACAE) on ethanol (EtOH)-induced cytotoxicity in Hep G2 cells. ACAE (1-100 mug/ml) dose-dependently inhibited the EtOH-induced tumor necrosis factor-alpha (TNF-alpha) secretion. ACAE (1-100 mug/ml) also inhibited the EtOH and TNF-alpha -induced cytotoxicity. Furthermore, we found that ACAE inhibited the TNF-alpha -induced apoptosis of Hep G2 cells. These results suggest that ACAE may prevent the EtOH-induced cytotoxicity through inhibition of the apoptosis of Hep G2 cells. (C) 2000 Published by Elsevier Science Ireland Ltd.

引用

页码：137 / 143

页数：7

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