Allogeneic mesenchymal stem cells for treatment of severe burn injury

被引：37

作者：

Jeschke, Marc G. ^{[1
,2
,3
,4
,5
]}

Rehou, Sarah ^{[1
,2
]}

McCann, Matthew R. ^{[1
]}

Shahrokhi, Shahriar ^{[2
,3
]}

机构：

[1] Sunnybrook Res Inst, Toronto, ON, Canada

[2] Sunnybrook Hlth Sci Ctr, Ross Tilley Burn Ctr, 2075 Bayview Ave D7 04, Toronto, ON M4N 3M5, Canada

[3] Univ Toronto, Fac Med, Dept Surg, Div Plast & Reconstruct Surg, Toronto, ON, Canada

[4] Univ Toronto, Fac Med, Dept Immunol, Toronto, ON, Canada

[5] Univ Toronto, Fac Med, Inst Med Sci, Toronto, ON, Canada

来源：

STEM CELL RESEARCH & THERAPY | 2019年 / 10卷 / 01期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

Burns; Cell therapy; Mesenchymal stem cells; Wound healing; AMNIOTIC MEMBRANE;

D O I：

10.1186/s13287-019-1465-9

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The most important determinant of survival post-burn injury is wound healing. For decades, allogeneic mesenchymal stem cells (MSCs) have been suggested as a potential treatment for severe burn injuries. This report describes a patient with a severe burn injury whose wounds did not heal with over 18 months of conventional burn care. When treated with allogeneic MSCs, wound healing accelerated with no adverse treatment complications. Wound sites showed no evidence of keloids or hypertrophic formation during a 6-year follow-up period. This therapeutic use of allogeneic MSCs for large non-healing burn wounds was deemed safe and effective and has great treatment potential.

引用

页数：6

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