Unleashing cell-penetrating peptide applications for immunotherapy

被引：22

作者：

Koo, Ja-Hyun ^{[1
,2
,6
]}

Kim, Gil-Ran ^{[1
]}

Nam, Kyung-Ho ^{[1
]}

Choi, Je-Min ^{[1
,3
,4
,5
]}

机构：

[1] Hanyang Univ, Coll Nat Sci, Dept Life Sci, Seoul 04763, South Korea

[2] Harvard Univ, Cambridge, MA USA

[3] Hanyang Univ, Res Inst Nat Sci, Seoul 04763, South Korea

[4] Hanyang Univ, Res Inst Convergence Seoul, Seoul 04763, South Korea

[5] Hanyang Univ, Hanyang Inst Biosci & Biotechnol, Seoul 04763, South Korea

[6] MIT, Massachusetts Gen Hosp, Ragon Inst, Cambridge, MA 02139 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2022年 / 28卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

PROTEIN-KINASE-C; DOUBLE-BLIND; NANOPARTICLE DELIVERY; CYTOPLASMIC DOMAIN; P53; UBIQUITINATION; ATOPIC-DERMATITIS; CYCLOSPORINE-A; TOPICAL GEL; INHIBITION; EFFICACY;

D O I：

10.1016/j.molmed.2022.03.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

With the advent of cancer immunotherapy, immunomodulation has emerged as an important strategy for the treatment of various diseases. We review recent advances in clinical trials of cell-penetrating peptide (CPP) applications for immunotherapy and also discuss their challenges and opportunities for preclinical studies in various immune diseases. CPP conjugation to antigenic peptides or proteins can enable efficient antigen uptake and cross-presentation by antigen presenting cells (APCs), which induce both humoral and cytotoxic responses. In addition, CPP-coupled immune modulators can enhance antitumor immunity or anti-inflammatory effects to regulate allergies and autoimmunity. Given their huge advantages in overcoming delivery barriers, CPP-based strategies for immunomodulation could extend drug optimization and advance immunotherapy in various human diseases.

引用

页码：482 / 496

页数：15

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