HEPATITIS B VIRUS DNA IN SALIVA FROM CHILDREN WITH CHRONIC HEPATITIS B INFECTION IMPLICATIONS FOR SALIVA AS A POTENTIAL MODE OF HORIZONTAL TRANSMISSION

被引：34
作者：
Heiberg, Ida Louise [1 ]
Hoegh, Mette [2 ]
Ladelund, Steen [3 ]
Niesters, Hubert G. M. [4 ]
Hogh, Birthe [1 ]
机构：
[1] Univ Copenhagen, Hvidovre Hosp, Dept Paediat, DK-2650 Hvidovre, Denmark
[2] Univ Copenhagen, Hvidovre Hosp, Dept Clin Microbiol, DK-2650 Hvidovre, Denmark
[3] Univ Copenhagen, Hvidovre Hosp, Clin Res Unit, DK-2650 Hvidovre, Denmark
[4] Univ Groningen, Univ Med Ctr Groningen, Dept Med Microbiol, Div Clin Virol, NL-9713 AV Groningen, Netherlands
来源：
PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2010年 / 29卷 / 05期
关键词：
chronic hepatitis B; children; HBV DNA; saliva; horizontal transmission; IMMUNIZATION PROGRAMS; PREVENTION; HBV;
D O I：
10.1097/INF.0b013e3181d8e009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To explore the mechanism of horizontal transmission of hepatitis B virus (HBV) among children, we investigated the quantitative relationship between HBV in saliva and blood from 46 children with chronic hepatitis B. We found high levels of HBV DNA in saliva of HBeAg (+) children, suggesting saliva as a vehicle for horizontal transmission of HBV among children.
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页码：465 / 467
页数：3
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