Estradiol regulates aryl hydrocarbon receptor expression in the rat uterus

被引：18
作者：
Kretzschmar, Georg [1 ]
Papke, Anja [1 ]
Zierau, Oliver [1 ]
Moeller, Frank Josef [1 ]
Medjakovic, Svjetlana [2 ,3 ]
Jungbauer, Alois [2 ,3 ]
Vollmer, Guenter [1 ]
机构：
[1] Tech Univ Dresden, Inst Zool, D-01062 Dresden, Germany
[2] Christian Doppler Lab Receptor Biotechnol, A-1190 Vienna, Austria
[3] Univ Nat Resources & Appl Life Sci Vienna, Dept Biotechnol, A-1190 Vienna, Austria
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2010年 / 321卷 / 02期
关键词：
Aryl hydrocarbon receptor; ARNT; Estradiol; Uterotrophic assay; Gene expression; ARYLHYDROCARBON RECEPTOR; GENE-EXPRESSION; AH RECEPTOR; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN; MOUSE; LIGANDS; TISSUE; CELLS;
D O I：
10.1016/j.mce.2010.02.018
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Several authors have investigated the role of aryl hydrocarbon receptor (AHR) in the reproductive tract, but there are no data available whether 17 beta-estrachol (E2) regulates expression of members of the AHR pathway in the uterus We therefore examined the mRNA expression of Ahr as well as the genes of the AHR dimerization partners ARNT1 and ARNT2 and the AHR regulated genes Cyp1a1 and Gsta2 in the uterus of ovariectomized rats after administration of E2 at two different doses The data show that Ahr mRNA expression is downregulated while AHR protein amounts increased in all uterine tissue compartments In addition we observed a downregulation of Arnt1, Arnt2 and Cyp1a1 while Gsta2 mRNA expression is upregulated by E2 in a dose-dependent manner These results show that members of the AHR pathway are regulated by E2 in the uterus AHR may therefore play an important role in the mediation of uterine estrogenic effects (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：253 / 257
页数：5
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