ACID-BASE PROPERTIES OF PENICILLINS AND CEPHALOSPORINS (A REVIEW)

被引：24
|
作者：
Alekseev, V. G. [1 ]
机构：
[1] Tver State Univ, Tver 170013, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2010年 / 44卷 / 01期
关键词：
acidity of penicillins; acidity of cephalosporins; CAPILLARY-ZONE-ELECTROPHORESIS; BETA-LACTAM ANTIBIOTICS; DISSOCIATION-CONSTANTS; AQUEOUS-SOLUTION; PHYSICOCHEMICAL PROPERTIES; IONIZATION-CONSTANTS; TERNARY COMPLEXES; PH-POTENTIOMETRY; DEGRADATION; STABILITY;
D O I：
10.1007/s11094-010-0389-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Published data on the acid-base properties of penicillin and cephalosporin antibiotics are summarized and systematized. It is suggested to classify penicillins and cephalosporins with respect to the acid-base type. The influence of the structure of antibiotics and the conditions and method used for determining the ionization constants of proton-donor groups in antibiotics are considered.
引用
收藏
页码：14 / 24
页数：11
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