Effectiveness of image-guided radiotherapy for laryngeal sparing in head and neck cancer

被引：22
作者：
Nguyen, Nam P. [1 ]
Ceizyk, Misty [1 ]
Vos, Paul [2 ]
Vinh-Hung, Vincent [3 ]
Davis, Rick [1 ]
Desai, Anand [1 ]
Abraham, Dave [1 ]
Krafft, Shane P. [1 ]
Jang, Siyoung [1 ]
Watchman, Christopher J. [1 ]
Ewell, Lars [1 ]
Hamilton, Russ [1 ]
Smith-Raymond, Lexie [1 ]
机构：
[1] Univ Arizona, Dept Radiat Oncol, Tucson, AZ 85724 USA
[2] E Carolina Univ, Greenville, NC USA
[3] Univ Hosp Geneva, Dept Radiat Oncol, Geneva, Switzerland
来源：
ORAL ONCOLOGY | 2010年 / 46卷 / 04期
关键词：
Head and neck cancer; IGRT; Laryngeal sparing; INTENSITY-MODULATED RADIOTHERAPY; RADIATION-THERAPY; HELICAL TOMOTHERAPY; NASOPHARYNGEAL CARCINOMA; IMRT; DYSPHAGIA; CHEMORADIATION; FIELD;
D O I：
10.1016/j.oraloncology.2010.01.010
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We would like to compare the effectiveness of image-guided (IGRT) and intensity-modulated (IMRT) radiotherapy to spare the larynx in head and neck cancer patients. A retrospective review of 48 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Mean laryngeal and hypopharyngeal dose was compared between 11 patients treated with IMRT and 37 patients treated with IGRT. Mean laryngeal dose was, respectively, 41.2 Gy and 22.8 Gy for the IMRT and IGRT technique (p < 0.001). The radiation dose to the middle and inferior pharyngeal muscles was also significantly reduced with the IGRT technique. Mean pharyngeal dose was, respectively, 52 Gy and 26 Gy for the IMRT and IGRT technique (p = 0.0001). Laryngeal sparing IGRT technique for head and neck cancer minimizes radiotherapy dose to the larynx and pharynx without sacrificing target coverage, even in the presence of neck lymph nodes. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：283 / 286
页数：4
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