Synthesis and antimicrobial activity of some novel 2-(substituted fluorobenzoylimino)-3-(substituted fluorophenyl)-4-methyl-1,3-thiazolines

被引：27

作者：

Saeed, Aamer ^{[1
]}

Shaheen, Uzma ^{[1
]}

Hameed, Abdul ^{[2
]}

Kazmi, Faiza ^{[2
]}

机构：

[1] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan

[2] Quaid I Azam Univ, Dept Microbiol, Islamabad 45320, Pakistan

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2010年 / 131卷 / 03期

关键词：

Antimicrobial activity; Fluorinated imino-1; 3-Thiazolines; Fluorinated 1.3-disubstituted thioureas; CRYSTAL-STRUCTURE; DERIVATIVES; RECEPTOR;

D O I：

10.1016/j.jfluchem.2009.11.005

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of several 2-(substituted fluorobenzoylimino)-3-(substituted fluorophenyl)-4-methyl-1,3-thiazolines (2a-t) was carried out by base-catalyzed cyclization of corresponding 1-(fluorobenzoyl)3-(fluorophenyl)thioureas (1a-t) with 2-bromoacetone in aqueous medium. The structures of the synthesized compounds were confirmed by spectral and elemental analysis. All synthesized compounds were evaluated for in vitro antibacterial activity using Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa). The minimum inhibitory concentration (MIC) was determined for the most active compounds. In vitro antifungal activity was also determined against the five fungal species (Rhizopus oryzae, Fusarium oxysporum, Aspergillus terreus, A. niger and A. fumigatus). (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：333 / 339

页数：7

共 28 条

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