Miyaura Borylation and One-Pot Two-Step Homocoupling of Aryl Chlorides and Bromides under Solvent-Free Conditions

被引：56

作者：

Dzhevakov, Pavel B. ^{[1
]}

Topchiy, Maxim A. ^{[1
]}

Zharkova, Daria A. ^{[2
]}

Morozov, Oleg S. ^{[1
]}

Asachenko, Andrey F. ^{[1
]}

Nechaev, Mikhail S. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, AV Topchiev Petrochem Synth Inst, Moscow 119991, Russia

[2] Moscow MV Lomonosov State Univ, Moscow 119991, Russia

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2016年 / 358卷 / 06期

关键词：

cross-coupling reactions; homocoupling; Miyaura borylation; palladium; solvent-free reactions; CROSS-COUPLING REACTION; PALLADIUM-CATALYZED BORYLATION; ORGANIC-SYNTHESIS; HALIDES; MICROWAVE;

D O I：

10.1002/adsc.201500844

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Solvent-free protocols for Miyaura borylation and the one-pot, two-step homocoupling of aryl halides are reported for the first time. Bis(di-benzylideneacetone) palladium(0) [Pd(dba)(2)] is an optimal source of palladium for Miyaura borylation, while for one-pot two-step homocoupling palladium(II) acetate [Pd(OAc)(2)] gives highest yields. Aryl bromides are coupled most efficiently using the DPEphos ligand. Chlorides are coupled using XPhos. The developed protocols are robust, versatile and easily reproducible on a large scale.

引用

页码：977 / 983

页数：7

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