DSCR1(Adapt78) -: A Janus gene providing stress protection but causing Alzheimer's disease?

被引：18

作者：

Ermak, G

Davies, KJA

机构：

[1] Univ So Calif, Ethel Percy Andrus Gerontol Ctr, Los Angeles, CA 90089 USA

[2] Univ So Calif, Div Mol & Computat Biol, Los Angeles, CA 90089 USA

来源：

IUBMB LIFE | 2003年 / 55卷 / 01期

关键词：

Alzheimer's disease; DSCR1 (Adapt78) gene; calcineurin;

D O I：

10.1080/1521654031000066820

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's disease is associated with the formation of paired helical filaments composed of hyperphospharylated tau protein. Phosphatase 2B, calcineurin can dephosphorylate the tau protein and, therefore, might prevent the assembly of paired helical filaments and even Alzheimer's disease. Calcipressin 1, the DSCR1 (Adapt78) gene product, can bind and inactivate calcineurin. Here we hypothesize that while short-term induction of calcipressin1 can provide stress protection, its long-term or chronic induction may cause gradual accumulation of hyperphosphorylated tau protein, eventually leading to Alzheimer's disease.

引用

页码：29 / 31

页数：3

共 16 条

[1]

Braak E, 1999, EUR ARCH PSY CLIN N, V249, P14

[2]

BRAAK H, 1966, ACTA NEUROL SCAND S, V165, P3

[3] The DSCR1 (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium-mediated stress damage, including transient oxidative stress [J].