Rapid polymorph screening on milligram quantities of pharmaceutical material using phonon-mode Raman spectroscopy

被引：31

作者：

Al-Dulaimi, Sarah ^{[1
]}

Aina, Adeyinka ^{[1
]}

Burley, Jonathan ^{[1
]}

机构：

[1] Univ Nottingham, Sch Pharm, Nottingham NG7 2RD, England

来源：

CRYSTENGCOMM | 2010年 / 12卷 / 04期

基金：

英国生物技术与生命科学研究理事会;

关键词：

FLUFENAMIC ACID; FORM-III; PARACETAMOL; CRYSTAL;

D O I：

10.1039/b921114b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We demonstrate that screening of pharmaceutical compounds for polymorphism can be rapidly achieved for milligram quantities of material using in situ phonon-mode Raman spectroscopy, and suggest that phonon-mode Raman spectra (10-400 cm(-1))can be used as "polymorphic fingerprints''.

引用

页码：1038 / 1040

页数：3

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