Rapid polymorph screening on milligram quantities of pharmaceutical material using phonon-mode Raman spectroscopy

被引：31
作者：
Al-Dulaimi, Sarah [1 ]
Aina, Adeyinka [1 ]
Burley, Jonathan [1 ]
机构：
[1] Univ Nottingham, Sch Pharm, Nottingham NG7 2RD, England
来源：
CRYSTENGCOMM | 2010年 / 12卷 / 04期
基金：
英国生物技术与生命科学研究理事会;
关键词：
FLUFENAMIC ACID; FORM-III; PARACETAMOL; CRYSTAL;
D O I：
10.1039/b921114b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We demonstrate that screening of pharmaceutical compounds for polymorphism can be rapidly achieved for milligram quantities of material using in situ phonon-mode Raman spectroscopy, and suggest that phonon-mode Raman spectra (10-400 cm(-1))can be used as "polymorphic fingerprints''.
引用
收藏
页码：1038 / 1040
页数：3
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