A SARS-coronovirus 3CL protease inhibitor isolated from the marine sponge Axinella cf. corrugata:: Structure elucidation and synthesis

被引:35
作者
de Lira, Simone P.
Seleghim, Mirna H. R.
Williams, David E.
Marion, Frederic
Hamill, Pamela
Jean, Francois
Andersen, Raymond J.
Hajdu, Eduardo
Berlinck, Roberto G. S.
机构
[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil
[2] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada
[3] Univ British Columbia, Dept Earth & Ocean Sci, Vancouver, BC V6T 1Z1, Canada
[4] Univ Fed Rio de Janeiro, Museu Nacl, BR-20940040 Rio De Janeiro, Brazil
基金
巴西圣保罗研究基金会;
关键词
esculetin; marine sponge; Axinella cf. corrugata; SARS; anti-viral;
D O I
10.1590/S0103-50532007000200030
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Two coumarin derivatives, esculetin-4-carboxylic acid methyl ester (1) and esculetin-4-carboxylic acid ethyl ester (2), have been isolated from the marine sponge Axinella cf. corrugata. Structure determination included analysis of spectroscopic data and total synthesis of compound 2. These are the first coumarin derivatives isolated from a marine sponge. The ethyl ester 2 was found to be an in vitro inhibitor of SARS 3CL-protease and an effective inhibitor of SARS-CoV replication in Vero cells at non-cytotoxic concentrations.
引用
收藏
页码:440 / 443
页数:4
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