Monotherapy trials of new antiepileptic drugs

被引：57

作者：

Beydoun, A

机构：

来源：

EPILEPSIA | 1997年 / 38卷

关键词：

epilepsy; clinical trials; monotherapy; antiepileptic drugs; double-blind trials;

D O I：

10.1111/j.1528-1157.1997.tb05201.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A number of clinical trials that test the efficacy and safety of the newer antiepileptic drugs (AEDs) have recently been concluded. Two dose-response trials in inpatients with refractory partial seizures and outpatients with newly diagnosed partial epilepsy established the efficacy of gabapentin as monotherapy. Lamotrigine was found to have efficacy similar to that of phenytoin and carbamazepine (CBZ) and to be better tolerated than CBZ in patients with newly diagnosed epilepsy. It was also shown to have efficacy as monotherapy in partial seizures, based on the results of an active controlled trial, and in the treatment of absence seizures, based on the results of a responder-enriched study. Topiramate as monotherapy was found to be efficacious for treatment of partial-onset seizures, based on the results of a single-center dose-response trial. A dose-response trial that tested the efficacy of tiagabine monotherapy in patients with refractory partial epilepsy was uninformative. Oxcarbazepine was found to be safe and efficacious in four comparative trials in patients with newly diagnosed epilepsy as well as in one placebo-controlled inpatient trial in patients with refractory partial seizures.

引用

页码：S21 / S31

页数：11

共 24 条

[11]

Chang Gregory, 1997, Neurology, V48, pA335

[12] Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-, 400-, and 600-mg daily dosages [J].

Faught, E ;

Wilder, BJ ;

Ramsay, RE ;

Reife, RA ;

Kramer, LD ;

Pledger, GW ;

Karim, RM ;

Barr, A ;

Fischer, J ;

Bergen, D ;

Boor, D ;

Browne, T ;

Davenport, J ;

Dichter, M ;

Drake, M ;

Kuzniecky, R ;

Mamdani, M ;

McCutchen, C ;

Naritoku, D ;

Potolicchio, S ;

Ramani, V ;

Ramsay, R ;

Shinnar, S ;

So, E ;

Wilder, B .

NEUROLOGY, 1996, 46 (06) :1684-1690

[13] A double-blind, placebo-controlled study of vigabatrin three g/day in patients with uncontrolled complex partial seizures [J].

French, JA ;

Mosier, M ;

Walker, S ;

Sommerville, K ;

Sussman, N ;

Barry, E ;

Bell, W ;

Bergen, D ;

Browne, T ;

Ferrendelli, J ;

Fisher, R ;

Fromm, G ;

Homan, R ;

Krauss, G ;

Lai, CW ;

Leppik, I ;

Leroy, R ;

Pellock, J ;

Penovich, P ;

Ramsay, RE ;

Shinnar, S .

NEUROLOGY, 1996, 46 (01) :54-61

[14] What trials, which designs? [J].

French, JA .

EPILEPSIA, 1997, 38 (03) :263-265

[15] HAZARDS OF INFERENCE - THE ACTIVE CONTROL INVESTIGATION [J].

LEBER, PD .

EPILEPSIA, 1989, 30 :S57-S63

[16] PLACEBO-CONTROLLED STUDY OF THE EFFICACY AND SAFETY OF LAMOTRIGINE IN PATIENTS WITH PARTIAL SEIZURES [J].

MATSUO, F ;

BERGEN, D ;

FAUGHT, E ;

MESSENHEIMER, JA ;

DREN, AT ;

RUDD, GD ;

LINEBERRY, CG ;

MADSEN, JA ;

RISTANOVIC, R ;

ERENBERG, G ;

KRAMER, RE ;

HARNER, RN ;

SCHOMER, DL ;

LEPPIK, I ;

COLLINS, SD ;

KING, KW ;

SHAMSNIA, M ;

WHITE, RL ;

GAY, PE ;

ROTHNER, AD ;

DRAKE, ME ;

DETOLEDO, J ;

SUSSMAN, NM ;

MIKATI, MA ;

OLSON, D ;

FROMM, G ;

MURRO, AM ;

EHLE, A ;

FOLEY, JF ;

MORRIS, HH ;

SMITH, DB ;

SO, EL ;

SCHACHTER, SC ;

KUZNIECKY, R ;

LAXER, K ;

GALLAGHER, BB ;

WEISBERG, LA ;

MOORE, EL .

NEUROLOGY, 1993, 43 (11) :2284-2291

[17] LAMOTRIGINE THERAPY FOR PARTIAL SEIZURES - A MULTICENTER, PLACEBO-CONTROLLED, DOUBLE-BLIND, CROSS-OVER TRIAL [J].

MESSENHEIMER, J ;

RAMSAY, RE ;

WILLMORE, LJ ;

LEROY, RF ;

ZIELINSKI, JJ ;

MATTSON, R ;

PELLOCK, JM ;

VALAKAS, AM ;

WOMBLE, G ;

RISNER, M .

EPILEPSIA, 1994, 35 (01) :113-121

[18]

OOMMEN K, 1993, NEUROLOGY, V43, P2292

[19] Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 600-, 800-, and 1,000-mg daily dosages [J].

Privitera, M ;

Fincham, R ;

Penry, J ;

Reife, R ;

Kramer, L ;

Pledger, G ;

Karim, R ;

Bourgeois, B ;

Carter, G ;

Ferrendelli, J ;

Fincham, R ;

Fromm, G ;

Gallagher, B ;

Harner, R ;

Holmes, M ;

Leroy, R ;

Penry, J ;

Privitera, M ;

Rosenfeld, W ;

Rowan, A ;

Sackellares, JC ;

Smith, D ;

Willmore, L ;

Wyler, A .

NEUROLOGY, 1996, 46 (06) :1678-1683

[20]

ROWAN J, 1993, EPILEPSIA S2, V34, P157

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