Two-Photon Active Organotin(IV) Carboxylate Complexes for Visualization of Anticancer Action

被引：60

作者：

Wang, Hui ^{[1
]}

Hu, Lei ^{[1
]}

Du, Wei ^{[1
]}

Tian, Xiaohe ^{[2
]}

Zhang, Qiong ^{[1
]}

Hu, Zhangjun ^{[3
]}

Luo, Lei ^{[4
]}

Zhou, Hongping ^{[1
]}

Wu, Jieying ^{[1
]}

Tian, Yupeng ^{[1
,5
]}

机构：

[1] Anhui Univ, Dept Chem, Key Lab Funct Inorgan Mat Chem Anhui Prov, Hefei 230601, Peoples R China

[2] Anhui Univ, Sch Life Sci, Hefei 230601, Peoples R China

[3] Linkoping Univ, Dept Phys Chem & Biol IFM, Div Mol Surface Phys & Nanosci, S-58183 Linkoping, Sweden

[4] Southwest Univ, Coll Pharmaceut Sci, Chongqing 400716, Peoples R China

[5] Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2017年 / 3卷 / 05期

基金：

中国国家自然科学基金;

关键词：

organotin carboxylate; two photon property; two-photon microscopy; anticancer agents; crystal structures; RUTHENIUM(II) POLYPYRIDYL COMPLEXES; IN-VITRO; CRYSTAL-STRUCTURES; CELLULAR UPTAKE; ACID SYNTHESIS; ANNEXIN-V; CELLS; APOPTOSIS; DERIVATIVES; TRACKING;

D O I：

10.1021/acsbiomaterials.6b00786

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

It is still a challenge that organotin(IV) carboxylate complexes with high-performance two-photon activity for cancer therapy. At present work, two novel organotin carboxylate complexes LSn1 and LSn2, containing coumarin moiety, were rationally designed for two-photon fluorescent imaging and anticancer purpose. The complexes possessed large two-photon action cross-sections and high quantum yields. Living cells evaluation revealed that complexes LSn1 and LSn2 exhibited good biocompatibility and deep tissue penetration over femtosecond laser with wavelength of 840 nm. Furthermore, the antitumor active and as well as possible mechanism of complexes LSn1 and LSn2 have been investigated systematically. The results indicated that complexes LSn1 and LSn2 could induce apoptotic cell death through a mitochondria] dysfunction and ROS elevation pathway. The present work provides a strategy for rationally designing organotin(IV) carboxylate complexes with two-photon activity and antitumor activity.

引用

页码：836 / 842

页数：7

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