Successful treatment of acute heart failure in COVID-19-induced cytokine storm with tocilizumab: a case report

被引：18

作者：

Chitturi, Kalyan R. ^{[1
]}

Thacker, Sameer ^{[1
]}

Al-Saadi, Mukhtar A. ^{[1
]}

Kassi, Mahwash ^{[2
]}

机构：

[1] Houston Methodist Hosp, Dept Med, Houston, TX 77030 USA

[2] Houston Methodist DeBakey Heart & Vasc Ctr, Dept Cardiol, Houston, TX USA

来源：

EUROPEAN HEART JOURNAL-CASE REPORTS | 2020年 / 4卷 / FI1期

关键词：

COVID-19; Heart failure; Takotsubo; Myocarditis; Cytokine; Tocilizumab; Case report;

D O I：

10.1093/ehjcr/ytaa188

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background SARS-CoV-2 is known to induce a cytokine storm, a hyperinflammatory state driven by up-regulation of interleukin 6 (IL-6) and immunomodulatory chemokines that may result in acute heart failure. Case summary A 65-year-old woman with confirmed SARS-CoV-2 developed shock with multiorgan system failure, including acute biventricular heart failure, 2 weeks after the initial onset of fever, cough, and shortness of breath. The patient experienced myocardial recovery within 48 h after administration of tocilizumab, a humanized monoclonal anti-IL-6 receptor antibody, and multiple supportive vasoactive medications. Discussion The differential diagnosis of acute heart failure in critically ill patients with COVID-19 infection is broad, including sepsis-induced cardiomyopathy, Takotsubo syndrome, viral lymphocytic myocarditis, and acute coronary syndrome. Immunomodulatory treatment with tocilizumab may benefit patients who develop cardiogenic shock associated with SARS-CoV-2-induced cytokine storm.

引用

页码：1 / 6

页数：6

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