Enantioselective Radical Addition/Cross-Coupling of Organozinc Reagents, Alkyl Iodides, and Alkenyl Boron Reagents

被引：106

作者：

Chierchia, Matteo ^{[1
]}

Xu, Peilin ^{[1
]}

Lovinger, Gabriel J. ^{[1
]}

Morken, James P. ^{[1
]}

机构：

[1] Boston Coll, Dept Chem, 2609 Beacon St, Chestnut Hill, MA 02467 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 40期

关键词：

boron; catalysis; cross-coupling; nickel; radical reactions; CATALYZED INTERMOLECULAR TRIFLUOROMETHYLARYLATION; POLAR CROSSOVER REACTIONS; REDUCTIVE DICARBOFUNCTIONALIZATION; UNACTIVATED OLEFINS; HALIDES; CYCLIZATION; STYRENES; ESTERS; 1,2-DIFUNCTIONALIZATION; DIFUNCTIONALIZATION;

D O I：

10.1002/anie.201908029

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A hybrid transition-metal/radical process is described that results in the addition of organozinc reagents and alkyl halides across alkenyl boron reagents in an enantioselective catalytic fashion. The reaction can be accomplished both intermolecularly and intramolecularly, providing useful product yields and high enantioselectivities in both manifolds.

引用

页码：14245 / 14249

页数：5

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