Reduced Occipital and Prefrontal Brain Volumes in Dysbindin-Associated Schizophrenia

被引：21

作者：

Donohoe, Gary ^{[1
,2
]}

Frodl, Thomas ^{[1
,2
,3
]}

Morris, Derek ^{[1
]}

Spoletini, Ilaria ^{[4
]}

Cannon, Dara M. ^{[5
]}

Cherubini, Andrea ^{[4
]}

Caltagirone, Carlo ^{[4
,6
]}

Bossu, Paola ^{[4
]}

McDonald, Colm ^{[5
]}

Gill, Michael ^{[1
,2
]}

Corvin, Aiden P. ^{[1
,2
]}

Spalletta, Gianfranco ^{[4
]}

机构：

[1] Univ Dublin Trinity Coll, Neuropsychiat Genet Res Grp, Dept Psychiat, Dublin 2, Ireland

[2] Univ Dublin Trinity Coll, Trinity Coll Inst Neurosci, Dublin 2, Ireland

[3] Univ Dublin Trinity Coll, Clin Neuroimaging Res Grp, Dept Psychiat, Dublin 2, Ireland

[4] IRCCS, Santa Lucia Fdn, Dept Clin & Behav Neurol, Rome, Italy

[5] Natl Univ Ireland Galway, Dept Psychiat, Clin Neuroimaging Lab, Galway, Ireland

[6] Univ Roma Tor Vergata, Dept Neurosci, Rome, Italy

来源：

NEUROPSYCHOPHARMACOLOGY | 2010年 / 35卷 / 02期

基金：

爱尔兰科学基金会;

关键词：

schizophrenia; MRI; voxel-based morphometry; dysbindin; DTNBP1; GENE; POPULATION; EXPRESSION; HAPLOTYPE; SAMPLES; LOCUS; RISK;

D O I：

10.1038/npp.2009.140

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A three-marker C-A-T dysbindin haplotype identified by Williams et al (PMID: 15066891) is associated with increased risk for schizophrenia, decreased mRNA expression, poorer cognitive performance, and early sensory processing deficits. We investigated whether this same dysbindin risk haplotype was also associated with structural variation in the gray matter volume (GMV). Using voxel-based morphometry, whole-volume analysis revealed significantly reduced GMVs in both the right dorsolateral prefrontal and left occipital cortex, corresponding to the behavioral findings of impaired spatial working memory and EEG findings of impaired visual processing already reported. These data provide important evidence of the influence of dysbindin risk variants on brain structure, and suggest a possible mechanism by which disease risk is being increased. Neuropsychopharmacology (2010) 35, 368-373; doi: 10.1038/npp.2009.140; published online 30 September 2009

引用

页码：368 / 373

页数：6

共 31 条

[1]

Allen Institute for Brain Science, 2009, ALL BRAIN ATL

[2] Unified segmentation [J].

Ashburner, J ;

Friston, KJ .

NEUROIMAGE, 2005, 26 (03) :839-851

[3] Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression [J].

Bray, NJ ;

Preece, A ;

Williams, NM ;

Moskvina, V ;

Buckland, PR ;

Owen, MJ ;

O'Donovan, MC .

HUMAN MOLECULAR GENETICS, 2005, 14 (14) :1947-1954

[4] Genetic variation in DTNBP1 influences general cognitive ability [J].

Burdick, KE ;

Lencz, T ;

Funke, B ;

Finn, CT ;

Szeszko, PR ;

Kane, JM ;

Kucherlapati, R ;

Malhotra, AK .

HUMAN MOLECULAR GENETICS, 2006, 15 (10) :1563-1568

[5] A POWER PRIMER [J].

COHEN, J .

PSYCHOLOGICAL BULLETIN, 1992, 112 (01) :155-159

[6] Comparison and validation of tissue modelization and statistical classification methods in T1-weighted MR brain images [J].

Cuadra, MB ;

Cammoun, L ;

Butz, T ;

Cuisenaire, O ;

Thiran, JP .

IEEE TRANSACTIONS ON MEDICAL IMAGING, 2005, 24 (12) :1548-1565

[7] Early visual processing deficits in dysbindin-associated schizophrenia [J].

Donohoe, Gary ;

Morris, Derek W. ;

De Sanctis, Pierfilippo ;

Magno, Elena ;

Montesi, Jennifer L. ;

Garavan, Hugh P. ;

Robertson, Ian H. ;

Javitt, Daniel C. ;

Gill, Michael ;

Corvin, Aiden P. ;

Foxe, John J. .

BIOLOGICAL PSYCHIATRY, 2008, 63 (05) :484-489

[8] Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: A preliminary study [J].

Donohoe, Gary ;

Morris, Derek W. ;

Clarke, Sarah ;

McGhee, Kevin A. ;

Schwaiger, Siobhan ;

Nangle, Jeanne-Marie ;

Garavan, Hugh ;

Robertson, Ian H. ;

Gill, Michael ;

Corvin, Aiden .

NEUROPSYCHOLOGIA, 2007, 45 (02) :454-458

[9]

FOLSTEIN MF, 1983, ARCH GEN PSYCHIAT, V40, P812

[10] Mapping IQ and gray matter density in healthy young people [J].

Frangou, S ;

Chitins, X ;

Williams, SCR .

NEUROIMAGE, 2004, 23 (03) :800-805

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