Synthesis and characterization of new pyrazole-tetrazole derivatives as new vasorelaxant agents

被引：12
|
作者：
Cherfi, Mounir [1 ]
Dib, Ikram [2 ]
Harit, Tarik [1 ]
Ziyyat, Abderrahim [2 ]
Malek, Fouad [1 ]
机构：
[1] Mohammed First Univ Bd Mohamed VI, Fac Sci, Lab Appl Chem & Environm ECOMP, BP 717, Oujda 60000, Morocco
[2] Mohammed I Univ, Fac Sci, Lab Bioresources Biotechnol Ethnopharmacol & Hlth, Oujda, Morocco
来源：
DRUG DEVELOPMENT RESEARCH | 2021年 / 82卷 / 07期
关键词：
pyrazole– tetrazole; spectroscopy; vasorelaxant activity;
D O I：
10.1002/ddr.21812
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of new functionalized tetrazole-pyrazole compounds is reported. They were fully characterized by spectroscopy and spectrometry methods. The vasorelaxant potency of these molecules was also investigated. All compounds showed a good vasorelaxant activity but the Compound 6 "ethyl 1-((2-(3-bromopropyl)-2H-tetrazol-5-yl)methyl)-5-methyl-1H-pyrazole-3-carboxylate" seems to have the highest effect, which reached 70% at 10(-4) M concentration. This effect was partially endothelium-dependent; also, the vasorelaxant pattern of this compound was quite similar to that of the verapamil.
引用
收藏
页码：1055 / 1062
页数：8
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