Synthesis and characterization of new pyrazole-tetrazole derivatives as new vasorelaxant agents

被引：12

作者：

Cherfi, Mounir ^{[1
]}

Dib, Ikram ^{[2
]}

Harit, Tarik ^{[1
]}

Ziyyat, Abderrahim ^{[2
]}

Malek, Fouad ^{[1
]}

机构：

[1] Mohammed First Univ Bd Mohamed VI, Fac Sci, Lab Appl Chem & Environm ECOMP, BP 717, Oujda 60000, Morocco

[2] Mohammed I Univ, Fac Sci, Lab Bioresources Biotechnol Ethnopharmacol & Hlth, Oujda, Morocco

来源：

DRUG DEVELOPMENT RESEARCH | 2021年 / 82卷 / 07期

关键词：

pyrazole– tetrazole; spectroscopy; vasorelaxant activity;

D O I：

10.1002/ddr.21812

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of new functionalized tetrazole-pyrazole compounds is reported. They were fully characterized by spectroscopy and spectrometry methods. The vasorelaxant potency of these molecules was also investigated. All compounds showed a good vasorelaxant activity but the Compound 6 "ethyl 1-((2-(3-bromopropyl)-2H-tetrazol-5-yl)methyl)-5-methyl-1H-pyrazole-3-carboxylate" seems to have the highest effect, which reached 70% at 10(-4) M concentration. This effect was partially endothelium-dependent; also, the vasorelaxant pattern of this compound was quite similar to that of the verapamil.

引用

页码：1055 / 1062

页数：8

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