The Association of Arsenic Exposure and Arsenic Metabolism With the Metabolic Syndrome and Its Individual Components: Prospective Evidence From the Strong Heart Family Study

被引:69
作者
Spratlen, Miranda J. [1 ,2 ]
Grau-Perez, Maria [3 ,4 ]
Best, Lyle G. [5 ]
Yracheta, Joseph [5 ]
Lazo, Mariana [6 ,7 ]
Vaidya, Dhananjay [6 ,7 ]
Balakrishnan, Poojitha [2 ]
Gamble, Mary V. [2 ]
Francesconi, Kevin A. [8 ]
Goessler, Walter [8 ]
Cole, Shelley A. [9 ]
Umans, Jason G. [10 ,11 ]
Howard, Barbara V. [10 ,11 ]
Navas-Acien, Ana [1 ,2 ]
机构
[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Environm Hlth & Engn, Baltimore, MD USA
[2] Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, 122 West 168th St,Room 1105, New York, NY 10032 USA
[3] Clin Res Fdn Valencia, Area Cardiometab & Renal Risk, Valencia, Spain
[4] Univ Valencia, Fac Math, Dept Stat & Operat Res, Valencia, Spain
[5] Missouri Breaks Ind Res Inc, Eagle Butte, SD USA
[6] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA
[7] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
[8] Graz Univ, Inst Chem, Dept Analyt Chem, Graz, Austria
[9] Texas Biomed Res Inst, San Antonio, TX USA
[10] MedStar Hlth Res Inst, Hyattsville, MD USA
[11] Georgetown Univ, Sch Med, Dept Med, Washington, DC USA
关键词
American Indians; arsenic; arsenic metabolism; indigenous populations; metabolic syndrome; prospective cohort studies; DEPENDENT DIABETES-MELLITUS; LOW-DENSITY-LIPOPROTEIN; DRINKING-WATER; CARDIOVASCULAR-DISEASE; METHYLATION CAPABILITY; AMERICAN-INDIANS; HYPERENDEMIC AREAS; NATIVE-AMERICANS; UNITED-STATES; ENDEMIC AREA;
D O I
10.1093/aje/kwy048
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Inorganic arsenic exposure is ubiquitous, and both exposure and interindividual differences in its metabolism have been associated with cardiometabolic risk. However, the associations of arsenic exposure and arsenic metabolism with the metabolic syndrome (MetS) and its individual components are relatively unknown. We used Poisson regression with robust variance to evaluate the associations of baseline arsenic exposure (urinary arsenic levels) and metabolism (relative percentage of arsenic species over their sum) with incident MetS and its individual components (elevated waist circumference, elevated triglycerides, reduced high-density lipoprotein cholesterol, hypertension, and elevated fasting plasma glucose) in 1,047 participants from the Strong Heart Family Study, a prospective family-based cohort study in American Indian communities (baseline visits were held in 1998-1999 and 2001-2003, follow-up visits in 2001-2003 and 2006-2009). Over the course of follow-up, 32% of participants developed MetS. An interquartile-range increase in arsenic exposure was associated with a 1.19-fold (95% confidence interval: 1.01, 1.41) greater risk of elevated fasting plasma glucose concentration but not with other individual components of the MetS or MetS overall. Arsenic metabolism, specifically lower percentage of monomethylarsonic acid and higher percentage of dimethylarsinic acid, was associated with higher risk of over all MetS and elevated waist circumference but not with any other MetS component. These findings support the hypothesis that there are contrasting and independent associations of arsenic exposure and arsenic metabolism with metabolic outcomes which may contribute to overall diabetes risk.
引用
收藏
页码:1598 / 1612
页数:15
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