Exercise and the hallmarks of peripheral arterial disease

被引:8
作者
Penin-Grandes, Saul [1 ]
Martin-Hernandez, Juan [1 ]
Valenzuela, Pedro L. [2 ]
Lopez-Ortiz, Susana [1 ]
Pinto-Fraga, Jose [1 ]
Sola, Lourdes del Rio [3 ]
Emanuele, Enzo [4 ]
Lista, Simone [5 ,6 ]
Lucia, Alejandro
Santos-Lozano, Alejandro [1 ,2 ]
机构
[1] European Univ Miguel de Cervantes, I HeALTH, Padre Julio Chevalier 2, Valladolid 47012, Castilla Y Leon, Spain
[2] Res Inst Hosp 12 Octubre, Imas12 PaHerg Grp, Madrid, Spain
[3] Univ Hosp Valladolid, Valladolid, Spain
[4] 2E Sci, Pavia, Italy
[5] Univ Roma Tor Vergata, Sch Pharm, Rome, Italy
[6] Univ Europea Madrid, Fac Sport Sci, Madrid, Spain
关键词
Atherosclerosis; Inflammation; Lower limb myopathy; Peripheral arterial disease; Physical exercise; Vascular dysfunction; QUALITY-OF-LIFE; ENDOTHELIAL PROGENITOR CELLS; C-REACTIVE PROTEIN; SKELETAL-MUSCLE; OXIDATIVE-STRESS; PHYSICAL-ACTIVITY; 6-MINUTE WALK; NITRIC-OXIDE; INTERMITTENT CLAUDICATION; CARDIOVASCULAR-DISEASE;
D O I
10.1016/j.atherosclerosis.2022.04.025
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Peripheral arterial disease (PAD) is a prevalent cardiovascular disease. The main hallmarks of this condition are atherosclerosis and myopathy in the lower limbs, with progressive deterioration of the functional capacity and quality of life of affected individuals. There is evidence supporting physical exercise as an effective alternative for the treatment of PAD. In this context, unraveling the biological mechanisms by which exercise intervention might improve the clinical manifestation of PAD can help gain insight into the pathophysiology of this condition, as well as explore new treatment and preventive approaches. In this review, we thus describe the different mechanisms by which exercise could impact the different hallmarks of PAD. Physical exercise positively modulates pathways related to inflammation and the atherosclerotic process and can attenuate the progression of lower-limb myopathy, with subsequent improvements in patients' functional capacity and health-related quality of life. At the whole-body level, these improvements translate into a better functional status and wellbeing.
引用
收藏
页码:41 / 50
页数:10
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