Macrophage functions in lean and obese adipose tissue

被引：205

作者：

Thomas, Dylan ^{[1
]}

Apovian, Caroline ^{[2
]}

机构：

[1] Boston Med Ctr, Sect Endocrinol Diabet Nutr & Weight Management, 88 East Newton St,H-3600, Boston, MA 02118 USA

[2] Boston Med Ctr, Sect Endocrinol Diabet Nutr & Weight Management, 88 East Newton St,Robinson 4400, Boston, MA 02118 USA

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2017年 / 72卷

关键词：

Macrophage; Adipose; Inflammation; Obesity; Fibrosis; Insulin; ACTIVATED PROTEIN-KINASE; ANTIGEN-PRESENTING CELLS; ACID-BINDING PROTEIN; DIET-INDUCED OBESITY; C-REACTIVE PROTEIN; FACTOR-KAPPA-B; INSULIN-RESISTANCE; T-CELLS; NLRP3; INFLAMMASOME; OXIDATIVE STRESS;

D O I：

10.1016/j.metabol.2017.04.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interactions between macrophages and adipocytes influence both metabolism and inflammation. Obesity-induced changes to macrophages and adipocytes lead to chronic inflammation and insulin resistance. This paper reviews the various functions of macrophages in lean and obese adipose tissue and how obesity alters adipose tissue macrophage phenotypes. Metabolic disease and insulin resistance shift the balance between numerous pro- and anti-inflammatory regulators of macrophages and create a feed-forward loop of increasing inflammatory macrophage activation and worsening adipocyte dysfunction. This ultimately leads to adipose tissue fibrosis and diabetes. The molecular mechanisms underlying these processes have therapeutic implications for obesity, metabolic syndrome, and diabetes. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：120 / 143

页数：24

共 253 条

[1] Vitamin E reduces adipose tissue fibrosis, inflammation, and oxidative stress and improves metabolic profile in obesity [J].

Alcala, Martin ;

Sanchez-Vera, Isabel ;

Sevillano, Julio ;

Herrero, Laura ;

Serra, Dolors ;

Pilar Ramos, M. ;

Viana, Marta .

OBESITY, 2015, 23 (08) :1598-1606

[2] Maternal Obesity in Pregnancy Developmentally Programs Adipose Tissue Inflammation in Young, Lean Male Mice Offspring [J].

Alfaradhi, Maria Z. ;

Kusinski, Laura C. ;

Fernandez-Twinn, Denise S. ;

Pantaleao, Lucas C. ;

Carr, Sarah K. ;

Ferland-McCollough, David ;

Yeo, Giles S. H. ;

Bushell, Martin ;

Ozanne, Susan E. .

ENDOCRINOLOGY, 2016, 157 (11) :4246-4256

[3] Diet-induced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge [J].

Amar, Salomon ;

Zhou, Qingde ;

Shaik-Dasthagirisaheb, Yazdani ;

Leeman, Susan .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (51) :20466-20471

[4] Omentectomy in addition to gastric bypass surgery and influence on insulin sensitivity: A randomized double blind controlled trial [J].

Andersson, Daniel P. ;

Thorell, Anders ;

Lofgren, Patrik ;

Wiren, Mikael ;

Toft, Eva ;

Qvisth, Veronica ;

Riserus, Ulf ;

Berglund, Lars ;

Naslund, Erik ;

Bringman, Sven ;

Thorne, Anders ;

Arner, Peter ;

Hoffstedt, Johan .

CLINICAL NUTRITION, 2014, 33 (06) :991-996

[5] Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects [J].

Apovian, Caroline M. ;

Bigornia, Sherman ;

Mott, Melanie ;

Meyers, Melissa R. ;

Ulloor, Jagadish ;

Gagua, Manana ;

McDonnell, Marie ;

Hess, Donald ;

Joseph, Lija ;

Gokce, Noyan .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2008, 28 (09) :1654-1659

[6] Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity [J].

Arner, Erik ;

Mejhert, Niklas ;

Kulyte, Agne ;

Balwierz, Piotr J. ;

Pachkov, Mikhail ;

Cormont, Mireille ;

Lorente-Cebrian, Silvia ;

Ehrlund, Anna ;

Laurencikiene, Jurga ;

Heden, Per ;

Dahlman-Wright, Karin ;

Tanti, Jean-Francois ;

Hayashizaki, Yoshihide ;

Ryden, Mikael ;

Dahlman, Ingrid ;

van Nimwegen, Erik ;

Daub, Carsten O. ;

Arner, Peter .

DIABETES, 2012, 61 (08) :1986-1993

[7] Human Adipose Tissue Macrophages: M1 and M2 Cell Surface Markers in Subcutaneous and Omental Depots and after Weight Loss [J].

Aron-Wisnewsky, Judith ;

Tordjman, Joan ;

Poitou, Christine ;

Darakhshan, Froogh ;

Hugol, Danielle ;

Basdevant, Arnaud ;

Aissat, Abdelhalim ;

Guerre-Millo, Michele ;

Clement, Karine .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (11) :4619-4623

[8]

Aronis KN, 2017, METAB CLIN EXP, V63, P979

[9] Adipocyte Inflammation Is Essential for Healthy Adipose Tissue Expansion and Remodeling [J].

Asterholm, Ingrid Wernstedt ;

Tao, Caroline ;

Morley, Thomas S. ;

Wang, Qiong A. ;

Delgado-Lopez, Fernando ;

Wang, Zhao V. ;

Scherer, Philipp E. .

CELL METABOLISM, 2014, 20 (01) :103-118

[10]

Athyros VG, 2017, METAB CLIN EXP

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