Diblock- and triblock-copolymer based mixed micelles with high tumor penetration in vitro and in vivo

被引：22

作者：

Cao, Xi ^{[1
]}

Zhou, Xu ^{[1
]}

Wang, Yu ^{[1
]}

Gong, Tao ^{[1
]}

Zhang, Zhi-Rong ^{[1
]}

Liu, Renhe ^{[2
]}

Fu, Yao ^{[1
]}

机构：

[1] Sichuan Univ, West China Sch Pharm, Minist Educ, Key Lab Drug Targeting & Delivery, 17,Sect 3,Southern Renmin Rd, Chengdu 610041, Peoples R China

[2] Scripps Res Inst, Dept Chem, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2016年 / 4卷 / 19期

关键词：

VITAMIN-E TPGS; POLYMERIC MICELLES; DRUG-DELIVERY; CELLULAR UPTAKE; P-GLYCOPROTEIN; MULTIDRUG-RESISTANCE; NANOPARTICLES; INHIBITION; MECHANISM; DESIGN;

D O I：

10.1039/c6tb00508j

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A series of self-assembled mixed micelles composed of TPGS and Pluronics were fabricated and their cellular uptake and exocytosis behaviors were studied in 2D cell and 3D tumor spheroid models. Together with in vivo efficacy studies, our results demonstrate that TPGS is not only critical to stabilize the mixed micelle structure but also to improve drug loading and facilitate cell penetration and accumulation.

引用

收藏

页码：3216 / 3224

页数：9

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