A highly efficient group-assisted purification method for the synthesis of poly-functionalized pyrimidin-5-yl-pyrroles via one-pot four-component domino reaction

被引：19
|
作者：
Dommaraju, Yuvaraj [1 ]
Prajapati, Dipak [1 ]
机构：
[1] CSIR North East Inst Sci & Technol, Div Med Chem, Jorhat 785006, Assam, India
来源：
MOLECULAR DIVERSITY | 2015年 / 19卷 / 01期
关键词：
Multicomponent reactions; Pyrrole; Pyrimidine; Chromatography; GAP chemistry; Green; sustainable chemistry; MCRs; CATALYTIC STRECKER REACTION; POLYSUBSTITUTED PYRROLES; MULTICOMPONENT REACTIONS; IMINE CHEMISTRY; ANALOGS; ET2ALCN; DESIGN;
D O I：
10.1007/s11030-014-9547-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A highly efficient, catalyst-free group-assisted purification chemical protocol for the construction of pyrimidine containing poly-functionalized pyrroles from a four-component domino reaction of acyclic-1,3-dicarbonyls or electron deficient alkynes, aromatic amines, barbituric acid and arylglyoxal hydrates under mild reaction conditions has been developed. The prominent features of the present protocol are environmentally benign, mild reaction conditions, atom economy, no column chromatography separation, easy isolation of products and excellent yields.
引用
收藏
页码：173 / 187
页数：15
相关论文
共 33 条
  • [1] A highly efficient group-assisted purification method for the synthesis of poly-functionalized pyrimidin-5-yl-pyrroles via one-pot four-component domino reaction
    Yuvaraj Dommaraju
    Dipak Prajapati
    Molecular Diversity, 2015, 19 : 173 - 187
  • [2] Highly Efficient Synthesis of Polysubstituted Pyrroles via Four-Component Domino Reaction
    Feng, Xian
    Wang, Qian
    Lin, Wei
    Dou, Guo-Lan
    Huang, Zhi-Bin
    Shi, Da-Qing
    ORGANIC LETTERS, 2013, 15 (10) : 2542 - 2545
  • [3] Solvent-free one-pot synthesis of highly functionalized benzothiazolediamides via Ugi four-component reaction
    Sheikholeslami-Farahani, F.
    Shahvelayati, A. S.
    BULGARIAN CHEMICAL COMMUNICATIONS, 2015, 47 (03): : 830 - 836
  • [4] An efficient copper catalyzed one-pot, four-component, and diastereoselective synthesis of highly functionalized ferrocenyl azetidinimines
    Gouthaman, Siddan
    Shanmugam, Ponnusamy
    Mandal, Asit Baran
    TETRAHEDRON LETTERS, 2013, 54 (23) : 3007 - 3010
  • [5] Chemoselective synthesis of fully substituted pyrroles via a one-pot four-component isocyanide-based reaction
    Nazeri, Mohammad Taghi
    Shaabani, Ahmad
    Notash, Behrouz
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2021, 19 (16) : 3722 - 3734
  • [6] An efficient one-pot synthesis of highly substituted [1,8]naphthyridin-1-phenyl-1-ethanone derivatives via a four-component reaction
    Alizadeh, Abdolali
    Roosta, Atefeh
    Halvagar, Mohammad Reza
    JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2017, 14 (10) : 2157 - 2165
  • [7] Nano-CoFe2O4 supported molybdenum as an efficient and magnetically recoverable catalyst for a one-pot, four-component synthesis of functionalized pyrroles
    Li, Bao-Le
    Zhang, Mo
    Hu, Hai-Chuan
    Du, Xia
    Zhang, Zhan-Hui
    NEW JOURNAL OF CHEMISTRY, 2014, 38 (06) : 2435 - 2442
  • [8] Efficient synthesis of new pyrano[2,3-d]pyrimidine-2,4-dione derivatives via a one-pot four-component reaction
    Irani, Sharmin
    Maghsoodlou, Malek Taher
    Hazeri, Nourallah
    JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2017, 14 (06) : 1189 - 1193
  • [9] Copper-catalyzed click synthesis of functionalized 1,2,3-triazoles with 3,4-dihydropyrimidinone or amide group via a one-pot four-component reaction
    Quan, Zheng-Jun
    Xu, Qiong
    Zhang, Zhang
    Da, Yu-Xia
    Wang, Xi-Cun
    TETRAHEDRON, 2013, 69 (02) : 881 - 887
  • [10] Polyaniline-supported acid as an efficient and reusable catalyst for a one-pot synthesis of β-acetamido ketones via a four-component condensation reaction
    Nabid, Mohammad Reza
    Rezaei, Seyed Jamal Tabatabaei
    APPLIED CATALYSIS A-GENERAL, 2009, 366 (01) : 108 - 113
1234