Analysis of the association between lactotransferrin (LTF) gene polymorphism and dental caries

被引：50

作者：

Azevedo, Luiza Foltran ^{[1
]}

Pecharki, Giovana Daniela ^{[1
]}

Brancher, Joao Armando ^{[1
]}

Cordeiro Junior, Carlos Alberto ^{[1
]}

dos Santos Medeiros, Kamilla Gabriella ^{[1
]}

Antunes, Alessandra Armstrong ^{[1
]}

Arruda, Eduardo Silva ^{[1
]}

Werneck, Renata Iani ^{[1
]}

de Azevedo, Luciana Reis ^{[1
]}

Mazur, Rui Fernando ^{[1
]}

Moyses, Samuel Jorge ^{[1
]}

Moyses, Simone Tetue ^{[1
]}

Faucz, Fabio Rueda ^{[1
]}

Trevilatto, Paula Cristina ^{[1
]}

机构：

[1] PUCPR, Ctr Hlth & Biol Sci, BR-80215901 Curitiba, Parana, Brazil

来源：

JOURNAL OF APPLIED ORAL SCIENCE | 2010年 / 18卷 / 02期

关键词：

Dental caries; ocurrence; LTF; Gene polymorphism; Exon; 2; HUMAN LACTOFERRIN GENE; SALIVA;

D O I：

10.1590/S1678-77572010000200011

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objective: The present study evaluated the association between lactotransferrin (LTF) gene polymorphism (exon 2, A/G, Lys/Arg) and dental caries. Material and Methods: A convenience sample of 110 individuals, 12 years old, was divided into: group 1, 48 individuals without caries experience (DMFT=0), and group 2, 62 subjects with caries experience (DMFT >= 1). DNA was obtained from a mouthwash with 3% glucose solution, followed by a scrapping of the oral mucosa. After DNA purification, polymerase chain reaction (PCR), single strand conformation polymorphism (SSCP) was performed to access the study polymorphism. The LTF A/G (Lys/Arg) polymorphism had been previously reported as located in exon 1. Results: Allele 1 of the study polymorphism was associated with low DMFT index and showed a protective effect against caries experience (OR=0.16, IC=0.030.76, p=0.01). Conclusion: Lactotransferrin A/G (exon 2, Lys/Arg) polymorphism was associated with susceptibility to dental caries in 12-year-old students.

引用

页码：166 / 170

页数：5

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