Immune response to HHV-6 and implications for immunotherapy

被引：23

作者：

Becerra, Aniuska ^{[1
]}

Gibson, Laura ^{[2
]}

Stern, Lawrence J. ^{[1
,3
]}

Calvo-Calle, J. Mauricio ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01605 USA

[2] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA USA

[3] Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, Worcester, MA USA

来源：

CURRENT OPINION IN VIROLOGY | 2014年 / 9卷

关键词：

HUMAN-HERPESVIRUS; 6; STEM-CELL TRANSPLANTATION; MYELIN BASIC-PROTEIN; T-CELLS; MULTIPLE-SCLEROSIS; MONOCLONAL-ANTIBODIES; CROSS-REACTIVITY; GLYCOPROTEIN-H; VARIANT B; NEUTRALIZING ANTIBODY;

D O I：

10.1016/j.coviro.2014.10.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Most adults remain chronically infected with HHV-6 after resolution of a primary infection in childhood, with the latent virus held in check by the immune system. latrogenic immunosuppression following solid organ transplantation (SOT) or hematopoetic stem cell transplantation (HSCT) can allow latent viruses to reactivate. HHV-6 reactivation has been associated with increased morbidity, graft rejection, and neurological complications post-transplantation. Recent work has identified HHV-6 antigens that are targeted by the CD4+ and CD8+ T cell response in chronically infected adults. T cell populations recognizing these targets can be expanded in vitro and are being developed for use in autologous immunotherapy to control post-transplantation HHV-6 reaction.

引用

页码：154 / 161

页数：8

共 69 条

[1] Classification of HHV-6A and HHV-6B as distinct viruses [J].

Ablashi, Dharam ;

Agut, Henri ;

Alvarez-Lafuente, Roberto ;

Clark, Duncan A. ;

Dewhurst, Stephen ;

DiLuca, Dario ;

Flamand, Louis ;

Frenkel, Niza ;

Gallo, Robert ;

Gompels, Ursula A. ;

Hollsberg, Per ;

Jacobson, Steven ;

Luppi, Mario ;

Lusso, Paolo ;

Malnati, Mauro ;

Medveczky, Peter ;

Mori, Yasuko ;

Pellett, Philip E. ;

Pritchett, Joshua C. ;

Yamanishi, Koichi ;

Yoshikawa, Tetsushi .

ARCHIVES OF VIROLOGY, 2014, 159 (05) :863-870

[2] Review Part 3: Human Herpesvirus-6 in Multiple Non-Neurological Diseases [J].

Ablashi, Dharam V. ;

Devin, Courtney L. ;

Yoshikawa, Tetsushi ;

Lautenschlager, Irmeli ;

Luppi, Mario ;

Kuehl, Uwe ;

Komaroff, Anthony L. .

JOURNAL OF MEDICAL VIROLOGY, 2010, 82 (11) :1903-1910

[3] N- and C-terminal external domains of human herpesvirus-6 glycoprotein H affect a fusion-associated conformation mediated by glycoprotein L binding the N terminus [J].

Anderson, RA ;

Gompels, UA .

JOURNAL OF GENERAL VIROLOGY, 1999, 80 :1485-1494

[4] IDENTIFICATION OF PROTEINS SPECIFIC FOR HUMAN HERPESVIRUS-6-INFECTED HUMAN T-CELLS [J].

BALACHANDRAN, N ;

AMELSE, RE ;

ZHOU, WW ;

CHANG, CK .

JOURNAL OF VIROLOGY, 1989, 63 (06) :2835-2840

[5] Efficacy Results of a Trial of a Herpes Simplex Vaccine [J].

Belshe, Robert B. ;

Leone, Peter A. ;

Bernstein, David I. ;

Wald, Anna ;

Levin, Myron J. ;

Stapleton, Jack T. ;

Gorfinkel, Iris ;

Morrow, Rhoda L. Ashley ;

Ewell, Marian G. ;

Stokes-Riner, Abbie ;

Dubin, Gary ;

Heineman, Thomas C. ;

Schulte, Joann M. ;

Deal, Carolyn D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (01) :34-43

[6] Antiviral drugs for cytomegalovirus diseases [J].

Biron, Karen K. .

ANTIVIRAL RESEARCH, 2006, 71 (2-3) :154-163

[7] Detection of antibodies directed against human herpesvirus 6 U94/REP in sera of patients affected by multiple sclerosis [J].

Caselli, E ;

Boni, M ;

Bracci, A ;

Rotola, A ;

Cermelli, C ;

Castellazzi, M ;

Di Luca, D ;

Cassai, E .

JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (11) :4131-4137

[8]

CHANG CK, 1991, J VIROL, V65, P7085, DOI 10.1128/JVI.65.12.7085-.1991

[9] Cross-reactivity of autoreactive T cells with MBP and viral antigens in patients with MS [J].

Cheng, Weizhi ;

Ma, Yanhui ;

Gong, Fang ;

Hu, Chaoying ;

Qian, Liu ;

Huang, Qiuyu ;

Yu, Qiwen ;

Zhang, Jiying ;

Chen, Shengdi ;

Liu, Zhengguo ;

Chen, Xuehua ;

Zhou, Tong ;

Zhang, Dongqing .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2012, 17 :1648-1658

[10] Human herpesvirus 6 and multiple sclerosis: A study of T cell cross-reactivity to viral and myelin basic protein antigens [J].

Cirone, M ;

Cuomo, L ;

Zompetta, C ;

Ruggieri, S ;

Frati, L ;

Faggioni, A ;

Ragona, G .

JOURNAL OF MEDICAL VIROLOGY, 2002, 68 (02) :268-272

← 1 2 3 4 5 6 7 →