A transdermal review on permeation of drug formulations, modifier compounds and delivery methods

被引：13

作者：

Rai, V. ^{[1
]}

Ghosh, I. ^{[2
]}

Bose, S. ^{[2
]}

Silva, S. M. C. ^{[3
,4
]}

Chandra, P. ^{[4
]}

Michniak-Kohn, B. ^{[1
,4
]}

机构：

[1] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Pharmaceut, Piscataway, NJ 08854 USA

[2] Novartis Pharmaceut, E Hanover, NJ 07936 USA

[3] Univ Coimbra, Fac Farm, P-3000548 Coimbra, Portugal

[4] New Jersey Ctr Biomat, Piscataway, NJ 08854 USA

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2010年 / 20卷 / 02期

关键词：

Percutaneous drug delivery; Formulation effect; Pig skin; Rat skin; Human skin equivalents; Permeation modifiers; Flux; Enhancers; Retardants; Biochemistry of skin; In vivo/in vitro correlation (IVIVC); Organization for Economic Co-operation and Development(OECD); RECONSTRUCTED HUMAN EPIDERMIS; CHEMICAL PENETRATION ENHANCERS; VITRO/IN-VIVO CORRELATION; HUMAN-SKIN PENETRATION; IN-VITRO; STRATUM-CORNEUM; PERMEABILITY BARRIER; PERCUTANEOUS PENETRATION; SPHINGOLIPID SYNTHESIS; GENE-EXPRESSION;

D O I：

10.1016/S1773-2247(10)50011-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This article systematically reviews the status of in vitro and in vivo percutaneous permeation of selected compounds reported in the literature and attempts to relate these permeation data to formulations and biochemical changes occurring in human skin, animal skins and skin equivalents. A substantial portion of the article is dedicated in reviewing the status of commercially available drugs and their delivery methods. Information on permeation modifier compounds and in vivo/in vitro (IVIVC) correlations is also provided in order to obtain a complete picture of the research status in the dermatopharmaceutical field.

引用

页码：75 / 87

页数：13

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