Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatum

被引：22

作者：

Schwendt, Marek ^{[1
]}

Hearing, Matthew C. ^{[1
]}

See, Ronald E. ^{[1
]}

McGinty, Jacqueline F. ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA

来源：

NEUROREPORT | 2007年 / 18卷 / 12期

关键词：

abstinence; addiction; cocaine; G-protein; in-situ hybridization; relapse;

D O I：

10.1097/WNR.0b013e328240507a

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuroadaptations affecting dopamine transmission within the prefrontal cortex and striatum are thought to underlie relapse to cocaine seeking after extended periods of abstinence. Regulator of G-protein signaling 4 (RGS4) is a forebrain-enriched protein known to be dynamically regulated by dopamine receptors in response to acute psychostimulant administration. In this report, chronic noncontingent (cocaine binge) or response-contingent (self-administration) delivery of cocaine followed by 2-3 weeks of abstinence resulted in a decrease of RGS4 mRNA in the dorsal striatum and prefrontal cortex. Furthermore, re-exposure to the cocaine-associated context after abstinence renewed the drug seeking and restored the levels of RGS4 mRNA to control values. Changes in RGS4 mRNA levels might signal abnormal receptor G-protein coupling that impacts cocaine seeking.

引用

页码：1261 / 1265

页数：5

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