Adherence to a Mediterranean diet, dyslipidemia and inflammation in familial hypercholesterolemia

被引：40

作者：

Antoniazzi, Luiza ^{[1
]}

Arroyo-Olivares, Raquel ^{[2
]}

Bittencourt, Marcio S. ^{[1
,3
,4
]}

Tada, Mauricio T. ^{[1
]}

Lima, Isabella ^{[1
]}

Jannes, Cinthia E. ^{[1
]}

Krieger, Jose E. ^{[1
]}

Pereira, Alexandre C. ^{[1
]}

Quintana-Navarro, Gracia ^{[5
]}

Muniz-Grijalvo, Ovidio ^{[6
]}

Diaz-Diaz, Jose L. ^{[7
]}

Alonso, Rodrigo ^{[8
]}

Mata, Pedro ^{[2
]}

Santos, Raul D. ^{[1
,9
]}

机构：

[1] Univ Sao Paulo, Heart Inst InCor, Med Sch Hosp, Sao Paulo, SP, Brazil

[2] Fdn Hipercolesterolemia Familiar, Madrid, Spain

[3] Sch Med, Facu Israelita Hlth Sci Albert Einstein, Sao Paulo, SP, Brazil

[4] Univ Hosp, Univ Sao Paulo Sch Med, Ctr Clin & Epidemiol Res, Sao Paulo, SP, Brazil

[5] IMIBIC, Hosp Univ Reina Sofia, Lipid Arteriosclerosis Unit, Cordoba, Spain

[6] Hosp Virgen Rocio, Internal Med Serv, Seville, Spain

[7] Hosp Abente Lago, Internal Med Serv, Coruna, Spain

[8] Ctr Adv Metab Med & Nutr, Santiago, Chile

[9] Hosp Israelita Albert Einstein, Sao Paulo, SP, Brazil

来源：

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | 2021年 / 31卷 / 07期

关键词：

Hyperliproteinemia type II; Cardiovascular diseases; Familial hypercholes-terolemia; Cholesterol; Inflammation; Mediterranean diet; FOOD FREQUENCY QUESTIONNAIRE; RISK-FACTORS; STYLE DIET;

D O I：

10.1016/j.numecd.2021.04.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and aims: Familial Hypercholesterolemia (FH) is characterized by elevated LDL-cholesterol (LDL-C) and high atherosclerosis risk. The impact of different dietary patterns on atherosclerosis biomarkers has been poorly studied in FH. This study verified the association of adherence to a Mediterranean diet with biomarkers of dyslipidemia and low-grade inflammation in molecularly proven FH adults from Brazil (BR) and Spain (SP). Methods and results: In this cross-sectional study adherence to the Mediterranean diet was assessed by a validated score and generalized estimating equations were used to evaluate its association with plasma LDL-C, apolipoprotein-B (ApoB) and high sensitivity C-reactive protein (hsCRP) concentrations. We included 92 (mean age 45 years, 58.7% females) and 98 FH individuals (mean age 46.8 years, 60.2% females) respectively from BR and SP. FH causing variants did not differ between countries. LDL-C, ApoB and hs-CRP concentrations were higher in BR than in SP: 179 (135-250) and 161 (133-193) mg/dL; 141 (109-181) and 103 (88-134) mg/dL; and 1.6 (0.8-4.0) and 0.8 (0.4-1.5) mg/L respectively (all p < 0.001). Most of BR had low adherence (n = 77, 83.7%), while the majority of SP were divided into moderate (n = 35, 35.7%) and strong adherence to the Mediterranean diet (n = 37, 37.8%), p < 0.001. There was a significant inverse association of adherence to the Mediterranean diet score with higher LDL-C, ApoB, and hs-CRP after adjusting for socio economic parameters, caloric and fatty acid intakes as well as pharmacological lipid lowering therapies. Conclusions: Higher adherence to a Mediterranean diet was associated with better dyslipidemia and low-grade inflammation profiles in FH. (c) 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

引用

页码：2014 / 2022

页数：9

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