Biomarkers in renal cell carcinoma: Towards a more selective immune checkpoint inhibition

被引：4

作者：

Sarkis, J. ^{[1
]}

Assaf, J. ^{[2
]}

Alkassis, M. ^{[1
]}

机构：

[1] Hotel Dieu France Hosp, Dept Urol, Beirut, Lebanon

[2] Hotel Dieu France Hosp, Dept Med, Beirut, Lebanon

来源：

TRANSLATIONAL ONCOLOGY | 2021年 / 14卷 / 06期

关键词：

Immunotherapy; Renal cell carcinoma; Biomarkers; PD-L1; TIM-3;

D O I：

10.1016/j.tranon.2021.101071

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune checkpoint inhibitors such as programmed death protein 1/programmed death-ligand 1 and cytotoxic T-lymphocyte?associated protein 4 inhibitors are already playing a central role in the treatment of metastatic renal cell carcinoma. However, they seem to be only effective in a subset of patients, with a high risk of innate and adaptive tumor resistance. Consequently, biomarkers capable of predicting immune treatment efficacy in advanced renal cancer are needed both in the clinical and the experimental setting. We hereby present a brief summary of evidence on the most studied biomarkers in metastatic renal cell carcinoma with a focus on the possible future place of T cell immunoglobulin and mucin domain-3 (TIM-3).

引用

页数：2