Nuclear magnetic relaxation dispersion profiles of substantia nigra pars compacta in Parkinson's disease patients are consistent with protein aggregation

被引：30

作者：

Lopiano, L

Fasano, M

Giraudo, S

Digilio, G

Koenig, SH

Torre, E

Bergamasco, B

Aime, S

机构：

[1] Univ Turin, Dept Neurosci, I-10126 Turin, Italy

[2] Univ Turin, IFM, Dept Chem, I-10125 Turin, Italy

[3] Bioind Pk Canavese, I-10010 Colleretto Giacosa, Italy

[4] Relaxometry Inc, Mahopac, NY 10541 USA

来源：

NEUROCHEMISTRY INTERNATIONAL | 2000年 / 37卷 / 04期

关键词：

D O I：

10.1016/S0197-0186(00)00036-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nuclear Magnetic Relaxation field-cycling relaxometry is a technique, able to report on water mobility in tissues. By means of this technique, post-mortem specimens from both controls and idiopathic Parkinson's disease patients have been investigated. Results show different relaxometric behavior between the groups, which is consistent with protein aggregation in Parkinson's disease specimens. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：331 / 336

页数：6

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